2004-2008年院内真菌感染动态变化及耐药性分析  

Dynamic Changes and Drug-resistance Analysis of Nosocomial Fungal Infections 2004-2008

作　　者：尚元元[1] 喻楠[1] 贾伟[2] 张云霞[2] 夏莉[1] 夏毓[3] 

机构地区：[1]宁夏医科大学附属医院皮肤性病科,宁夏银川750004 [2]宁夏医科大学附属医院检验科,宁夏银川750004 [3]张掖市人民医院皮肤科,甘肃张掖734000

出　　处：《中华医院感染学杂志》2010年第16期2519-2521,共3页Chinese Journal of Nosocomiology

基　　金：宁夏回族自治区教育厅科研资助项目(2006)

摘　　要：目的探讨医院院内深部真菌感染5年的动态变化趋势及其耐药情况。方法对2004-2008年的住院患者深部真菌感染进行调查,药敏试验采用法国生物梅里埃公司ATBFungus3药敏卡。结果 5年院内深部真菌感染标本的检出率呈下降趋势(P<0.05),院内深部真菌感染的主要部位是呼吸道,599株假丝酵母菌属对氟康唑、两性霉素B、伊曲康唑、5-氟胞嘧啶的敏感率分别为69.62%、97.96%、65.94%、96.16%。结论采取积极的措施,做好预防工作,可以减少院内深部真菌感染的概率,氟康唑和伊曲康唑耐药性在逐年增加。OBJECTIVE To investigate the trend of dynamic change and drug-resistance situation of nosocomial fungal infection in recent years.METHODS A survey of nosocomial fungal infection was conducted on patients hospitalized in our hospital between 2004 and 2008.The susceptibility test was determined by ATB Fungus3 of bio-Merieux of France.RESULTS The detection rate of nosocomial fungal infection decreased in recent 5 years.Nosocomial fungal infection occurred mainly in respiratory tract.The susceptibility rate to fluconazole,amphotericin B,itraconazole,and flucytosine was 69.62%,97.96%,65.94% and 96.16%,respectively.CONCLUSION To take positive and preventive measures can reduce deep nosocomial fungal infection.Drug resistance to fluconazole and itraconazole is increasing year by year.

关 键 词：医院感染 真菌 动态变化 耐药性分析 

分 类 号：R379[医药卫生—病原生物学]