齐拉西酮治疗老年期精神分裂症阴性症状的对照研究  

Control study of ziprasidone in treatment of elderly negative symptoms of senile schizophrenia

作　　者：黄峰 

机构地区：[1]桂林市社会福利医院,广西桂林541001

出　　处：《现代医药卫生》2010年第18期2745-2747,共3页Journal of Modern Medicine & Health

摘　　要：目的:比较齐拉西酮和舒必利治疗以阴性症状为主的老年期精神分裂症的疗效和安全性。方法:将76例以阴性症状为主的老年期精神分裂症患者随机分为齐拉西酮组(38例)和舒必利组(38例),分别给予齐拉西酮和舒必利治疗,疗程8周。采用阳性与阴性症状量表(PANSS)和阴性症状评定量表(SANS)评定疗效,不良反应量表(TESS)评定不良反应。结果:治疗8周后,齐拉西酮组总有效率为81.58%,舒必利组总有效率为78.95%,两组疗效差异无统计学意义(P>0.05)。齐拉西酮与舒必利对阴性症状均有较好疗效,齐拉西酮组不良反应的程度较舒必利组轻。结论:齐拉西酮治疗以阴性症状为主的老年期精神分裂症疗效确切,不良反应轻。Objective：To compare the curative ffect and safety of ziprasidone and sulpiride treatment of elderly schizophrenia with predominantly negative symptoms.Methods：The 76 senile patients with predominantly negative symptoms of schizophrenia were randomly divided into ziprasidone group （38 cases） and sulpiride group （38 cases）,and treated with ziprasidone and sulpiride respectively for 8 weeks.Using Positive and Negative Syndrome Scale （PANSS） and negative symptom rating scale （SANS） to assess the efficacy,side effects scale （TESS） was used to assess the adverse reactions.Results：After 8 weeks of treatment,ziprasidone total effective rate was 81.58%, sulpiride total effective rate was 78.95%,without significant difference between two groups.Ziprasidone and sulpiride on negative symptoms had good effect.In ziprasidone group,the extent of adverse reactions was lighter than that in sulpiride group.Conclusion：Ziprasidone in treatment of predominantly negative symptoms of senile schizophrenia has definite eflect with less adverse reaction.

关 键 词：齐拉西酮 舒必利 老年期精神分裂症 阴性症状 

分 类 号：R5[医药卫生—内科学]