β_2肾上腺素受体Arg16Gly基因多态性与原发性高血压的相关性研究  

The study of relationship between β_2-adrenoceptor Arg16Gly gene polymorphism and essential hypertension

作　　者：彭应心[1] 薛浩[2] 姚文静[1] 于薇[1] 容春莉[1] 曹东平[1] 王夕月[1] 李秀芳[1] 

机构地区：[1]河北省人民医院心内科,石家庄050051 [2]中国人民解放军总医院心内科

出　　处：《临床心血管病杂志》2010年第7期507-510,共4页Journal of Clinical Cardiology

摘　　要：目的:研究河北地区汉族人β2肾上腺素受体(β2-Adrenergic Receptor,β2-AR)Arg16Gly基因多态性与原发性高血压(EH)的关系。方法:选择514例EH患者及550例正常人,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析β2-ARArg16Gly基因型。结果:EH组β2-ARArg16Arg,Arg16Gly,Gly16Gly基因型频率分别为21.3%、54.8%和23.9%,正常对照组分别为28.2%、68.2%和3.6%,2组间3种基因型频率差异有统计学意义(P<0.05)。EH组β2-ARArg16等位基因频率为51.8%,Gly16等位基因频率为48.2%;正常对照组分别为63.9%和36.1%,2组间等位基因频率比较,差异有统计学意义(P<0.05)。结论:β2-ARArg16Gly多态性Gly等位基因可能是EH的遗传易感基因。Objective：To study the relationship between polymorphism of β2-adrenoceptor （β2-AR） gene at locus 16 （Arg/Gly） and essential hypertension （EH）.Method：514 hypertensives and 550 normotensives were involved.β2-AR genotypes were determined,by polymerase chain reaction （PCR-RFLP）.Result：The observed genotype frequencies in the EH and control groups were in Hardy-Weinberg equation （P〈0.05）.The frequencies of three genotypes （Arg/Arg,Arg/Gly and Gly/Gly） were21.3%,54.8% and 23.9% in hypertensives and 28.2%,68.2% and 3.6% in controls respectively.The distributions of the genotypes were significantly different between two groups （P〈0.05）.The frequencies of Arg and Gly allele in hypertensives were 51.8% and 48.2% respectively;in controls were 63.9% and 36.1% respectively.The allele frequencies were significantly different between two groups （P〈0.05）.Conclusion：β2-AR Arg16Gly gene polymorphism was possibly associated with EH in this study population.

关 键 词：高血压 Β2肾上腺素能受体 基因多态性 

分 类 号：R541.7[医药卫生—心血管疾病]