布洛芬/星形聚乳酸缓释微球的制备及其释放特性  

Preparation s-PLLA/Ibuprofen micro-spheres and its in vitro releasing properties

作　　者：林雅铃[1] 张安强[2] 

机构地区：[1]华南农业大学资源环境学院制药工程系,广东广州510640 [2]华南理工大学材料科学与工程学院高分子材料科学与工程系,广东广州510641

出　　处：《中国医院药学杂志》2010年第15期1269-1272,共4页Chinese Journal of Hospital Pharmacy

基　　金：广东省自然科学基金资助项目(编号:07300675)

摘　　要：目的:制备布洛芬/星形聚乳酸载药微球,研究制备工艺参数对载药微球的药物包封率的影响,并对其体外释放特性进行表征。方法:以星形聚L-乳酸(s-PLLA)为聚合物基材,采用溶剂挥发法制备布洛芬/星形聚乳酸载药微球(s-PLLA/IBU),采用正交试验设计的方法安排试验,研究s-PLLA/IBU的体外缓释特性,并用傅里叶变换红外光谱计(FTIR)和扫描电镜(SEM)对微球进行表征。结果:通过极差分析与方差分析建立s-PLLA/IBU的药物包封率与制备工艺参数之间的关系,并在此基础上遴选出优化工艺。IBU与s-PLLA结合良好,s-PLLA/IBU微球缓释7d后,s-PLLA出现部分降解。采用优化工艺所制备的s-PLLA/IBU微球的释放特性符合一级方程。结论:采用溶剂挥发法制备的s-PLLA/IBU微球的药物包封率高、体外释药平稳。OBJECTIVE To prepare star-shaped poly（L-lactide） loaded ihuprofen （s-PLLA/IBU） micro spheres and study the influence of preparation technologies on drug encapsulation efficiency （DEE） of s-PLLA/SH micro spheres, and study its in vitro drug release. METHODS s-PLLA/IBU micro spheres were prepared using the method of solvent evaporation. To optimize the preparation technology, an orthogonal design scheme was applicd. FTIR and SEM were applied to characterize s-PLLA/IBU micro-spheres. RESULTS The optimized preparation technology was obtained based on range analysis and variance analysis. IBU could combine with s-PLLA well, and part of s-PLLA were degraded after 7d in vitro releasing. The release curve of optimized s-PLLA/IBU micro-spheres could be well fitted by the first-order equation. CONCLUSION The results showed that the drug encapsulation efficiency of s-PLLA/IBU micro-spheres is high and the release of ibuprofen from micro-spheres is slow and steady.

关 键 词：布洛芬 星形聚乳酸载药微球 包封率 体外释放 

分 类 号：R943[医药卫生—药剂学]