干扰素调节因子3的激活  

Progress of Interferon regulatory factor 3 in signaling pathway

作　　者：王怡[1] 周国平[1] 

机构地区：[1]南京医科大学第一附属医院儿科,南京210029

出　　处：《生命的化学》2010年第4期523-527,共5页Chemistry of Life

基　　金：国家自然科学基金资助项目(No30570863);国家自然科学基金资助项目(No30872804);江苏省"科教兴卫工程"医学重点人才项目(NoRC2007050);江苏省自然科学基金(NoBK2007244)资助

摘　　要：干扰素调节因子3(interferon regulatory factor-3,IRF-3)是调节Ⅰ型干扰素基因表达的关键转录因子,它的活化将影响IFN基因的表达。IRF-3的磷酸化受多条信号转导通路及相关分子的调控。在有关的调控中,RIG-I/MDA-5-MAVS与IRF-3的活化关系较为密切,RIG-I/MDA-5识别病原相关分子模式(PAMP),经中间蛋白质MAVS激活下游激酶复合体TBK1/IKKε,通过不同机制活化转录因子IRF-3。在此通路中,有TRAF3、NEMO、TRADD等分子参与,最近有研究发现,TRAF5、STING、WDR5亦参与调控,在调节IRF-3的活化过程中发挥重要作用。通过对IRF-3激活的研究,将有助于阐明病毒诱导机体产生先天性免疫和特异性免疫的分子机制。Interferon regulatory factor-3（IRF-3） is the key transcription factor in the regulation of type I interferon（IFN） gene expression,and its activation will affect the IFN gene expression.Regulation of IRF-3 itself has been studied mainly in the protein phosphorylation,and the phosphorylation is regulated by multiple signal transduction pathways and related molecules.In these pathways,RIG-I/MDA-5-MAVS has closer relationship with the activation of IRF-3.RIG-I/MDA-5 can recognize pathogen-associated molecular pattern（PAMP）.They activate the downstream kinase complex TBK1/IKKe by the middle protein MAVS and transcription factor IRF-3 through different mechanisms.In this pathway,such molecules as TRAF3,NEMO and TRADD are involved in the activation of transcription factor IRF-3.Recent studies have found that TRAF5,STING and WDR5 play important roles in the regulation of the activation of IRF-3 by this pathway.It will help clarify mechanisms of virus-induced innate immunity and adaptive immunity by studying IRF-3 signaling pathway.

关 键 词：干扰素调节因子3 信号通路 线粒体抗病毒信号传送蛋白 

分 类 号：R392[医药卫生—免疫学]