RBL-2H3细胞系在过敏性疾病中的应用  

Application of RBL-2H3 cell line in allergic diseases

作　　者：陈萍[1] 房林华[1] 

机构地区：[1]山东大学附属省立医院,济南250021

出　　处：《生命的化学》2010年第4期586-589,共4页Chemistry of Life

摘　　要：肥大细胞在过敏性疾病发生中起关键作用,而RBL-2H3细胞系作为大鼠嗜碱性粒细胞系(rat basophilic leukemia,RBL)的一个亚系,可以表达肥大细胞的许多特性和功能,因此常作为过敏性疾病研究的替代模型。RBL-2H3细胞系常用作过敏反应中肥大细胞脱颗粒和激活机制方面的研究,此外,该细胞系在抗原特异性IgE的检测、过敏原的分离鉴定和临床过敏性疾病诊断等方面也有较高的应用价值。本文重点综述了RBL-2H3细胞系在过敏性疾病研究的多个领域中的应用情况。Mast cells play a pivotal role in the development of allergic diseases.The RBL-2H3（rat basophilic leukemia） cell line,although as a subline of rat basophilic leukemia cell line（RBL）,resembles some characteristics of mast cells and is commonly used as an in vitro cell line in the allergy research.The RBL-2H3 cell line is widely used to the studies on the functions of mast cells and its activation mechanisms.Besides,RBL cell line is regarded as a suitable model in antigen-specific IgE measurement.This review will focus on the application of RBL-2H3 cell line in many aspects of allergic diseases and anticipate its prospect.

关 键 词：肥大细胞 RBL-2H3细胞系 过敏性疾病 过敏原特异性IGE 

分 类 号：R593[医药卫生—内科学]