渔村与砷暴露地区居民尿砷代谢产物检测比较  

Comparison of urinary arsenic metabolites between fishing village residents and residents exposed to arsenic in drinking water

作　　者：朱博[1] 徐磊[1] 郑全美[1] 席淑华[1] 侯勇勇[1] 蔡偌欣[1] 孙贵范[1] 

机构地区：[1]中国医科大学公共卫生学院劳动卫生教研室,沈阳110001

出　　处：《中国公共卫生》2010年第8期1085-1086,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金重点项目(30530640);国家科技支撑项目(2006BAI06B04)

摘　　要：目的测定渔村居民和饮水型砷暴露地区人群尿中各种形态砷和尿总砷(TAs)。方法选取饮水型砷暴露地区〔口肯板村水砷浓度为0.16 mg/L;乃莫板村水砷浓度为0.09 mg/L;塔布塞村(对照组)饮用水砷浓度<0.01 mg/L〕和渔村居民。采用氢化物发生原子吸收分光光度法检测尿中各形态砷代谢物和TAs含量。结果 TAs含量渔村居民明显低于0.16 mg/L暴露组,高于对照组(P<0.05),与0.09 mg/L暴露组差异无统计学意义;渔村居民尿无机砷(iAs)含量明显低于0.09和0.16 mg/L暴露组(P<0.05);尿甲基砷(MMA)含量同尿二甲基砷(DMA)含量,各组之间差异均有统计学意义(P<0.05);渔村居民尿iAs百分比明显低于对照组、0.09和0.16 mg/L暴露组(P<0.05);尿MMA百分比同尿iAs百分比;各组尿DMA百分比差异均有统计学意义(P<0.05);渔村居民特异性的检测出尿三甲胺(TMA)。结论人群尿总砷水平受食用海产品等因素影响,不能单独作为砷暴露指标,应使用分析性方法来区分砷复合物中无机砷和有机砷的代谢产物。Objective To determine the arsenic metabolites and total arsenic（TAs）in the urine of fishing village residents and residents exposed to arsenic in drinking water.Methods Three villages in Inner Mongolia with high（0.16 mg/L,0.09 mg/L） and normal arsenic（0.01 mg/L） in drinking water and a fishing village were selected.Hydride generation atomic absorption spectroscopy was used to detect urinary arsenic species among residents of the villages.Results The TAs of the residents in fishing village was lower than that of in residents exposed to water with 0.16 mg/L arsenic and higher than that of with 0.09 mg/L（P0.05）.Urinary inorganic arsenic（iAs） in residents of fishing village was lower than that of the residents exposed to water with 0.09 mg/L and 0.16 mg/L arsenic with significanct differences between the residents of the four groups.The percent of urinary iAs in residents of fishing village was lower than that of residents in other three villages（P0.05）.There were significant differences in urinary methyl arsenic and dimethyl arsenic between the residents of the four villages.Urinary trimethyl arsenic was detected only in residents of the fishing village.Conclusion Urinary TAs can not be used as the only indicator of arsenic exposure.Analytical methods must be used to distinguish urinary metabolite of inorganic arsenic and organic arsenic.

关 键 词：无机砷 尿砷 砷暴露 

分 类 号：R995[医药卫生—毒理学]