基于信息熵关联度系数法的慢性肾功能衰竭中医症状组合的探索  

Combinations of TCM symptoms in chronic renal failure based on relational analysis of information entropy

作　　者：王天芳[1] 李志更[2] 吴秀艳[1] 王庆国[1] 陈建新[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]中国中医科学院基础理论研究所

出　　处：《北京中医药大学学报》2010年第7期493-495,499,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2003CB517106和No.2003CB517101)

摘　　要：目的运用信息熵关联度系数法探讨慢性肾功能衰竭的常见中医症状组合及其意义。方法运用信息熵关联度系数法,对通过临床采集的601例慢性肾功能衰竭患者的108个中医临床症状数据(未经事先辨证)进行分析。结果经对获得的慢性肾功能衰竭21个中医症状组合的初步诠释,发现存在有心气虚、脾气虚、脾胃气虚、肾阳虚、气阴两虚、肝气郁结、肝脾不调、肝胃不和、脾胃不和、津亏血虚、血虚阳虚、气虚湿阻、血瘀血虚、阳虚水停、热盛伤津等常见中医证候类型,涉及的病位类证候要素为心、脾、胃、肾、肝,病性类证候要素为气虚、阳虚、阴虚、血虚、津亏、气滞、气逆、湿阻、血瘀、水停、热(火)盛等。结论通过运用信息熵关联度系数分析方法对临床调查的慢性肾功能衰竭中医症状数据进行分析,所获取的症状组合可为提取该病的常见证候及证候要素的研究提供依据。Objective To study the combinations of common TCM symptoms and their significance in chronic renal failure（CRF） by applying the relational analysis of information entropy.Method The relational analysis of information entropy was used to analyse 108 TCM symptoms（without prior syndrome differentiation） in 601 CRF patients selected from the clinic.Result After the initial analysis on 21 combinations of TCM symptoms of CRF,common TCM syndrome types were found as follows：heart qi deficiency,spleen qi deficiency,spleen-stomach qi deficiency,kidney yang deficiency,dual deficiency of qi and yin,liver qi stagnation,liver-spleen disharmony,liver-stomach disharmony,spleen-stomach disharmony,fluid depletion and blood deficiency,blood and yang deficiency,qi deficiency and dampness obstruction,blood stasis and blood deficiency,yang deficiency and water retention,and exuberant heat damaging fluid.The involved syndrome factors related to disease location included heart,spleen,stomach,kidney and liver.The syndrome factors related to disease nature included qi deficiency,yang deficiency,yin deficiency,blood deficiency,fluid depletion,qi stagnation,qicounterflow,dampness obstruction,blood stasis,water retention,and exuberant heat（fire） .Conclusion The TCM symptom data of CRF based on clinical survey are studied through applying the relational analysis of information entropy,and the obtained symptom combinations of CRF can provide a base for the research on CRF common syndromes and syndrome factors.

关 键 词：关联度系数 信息熵 慢性肾功能衰竭 症状 证候 证候要素 

分 类 号：R269.25[医药卫生—中西医结合]