泮托拉唑治疗非食管静脉曲张性上消化道出血60例  

Clinical Observation of Pantoprazole in Treatment of Non-Esophageal Variceal Upper Gastrointestinal Hemorrhage

作　　者：张淑平[1] 张磊[1] 代加平 

机构地区：[1]四川省宜宾市第一人民医院,四川宜宾644000 [2]四川省宜宾卫生学校,四川宜宾644000

出　　处：《中国药业》2010年第15期66-67,共2页China Pharmaceuticals

摘　　要：目的观察泮托拉唑治疗非食管静脉曲张性上消化道出血的临床疗效。方法将100例患者随机分成两组,治疗组60例予泮托拉唑80mg静脉滴注,每日1次,连续3～5d;对照组40例予奥美拉唑40mg静脉注射,每日2次,连续5d。观察两组给药后3d和5d临床症状改善情况及实验室指标或内镜下止血征象。结果治疗组总有效率为91.67%,对照组为95.00%,差异无统计学意义(P>0.05);但平均止血时间治疗组为(47.3±3.5)h,明显短于对照组的(75.6±4.2)h。结论泮托拉唑治疗非食管静脉曲张性上消化道出血疗效显著,与奥美拉唑相当,不良反应少,安全性好。Objective To observe the clinical effect of pantoprazole in the treatment of nonesophageal variceal upper gastrointestinal hem- orrhage. Methods One hundred patients were randomly divided into two groups： 60 cases in the treatment group and 40 cases in the control group. The clinical symptoms, laboratory indicators and endoscopic haemostasis were observed in two groups on 3 d and 5 d after treatment. Results The total effective rate was 91.67% in the treatment group and 95.00% in the control group respectively. There was no significant difference between the two groups（P〉 0.05）. But the average haemostasis time was （47.3 ±3.5）h in the treatment group and （75.6 ±4. 2）h in the control group, the former was obviously shorter than the latter. Conclusion The efficacy of pantoprazole for treating non- esophageal variceal upper gastrointestinal hemorrhage is remarkable and equivalent to the efficacy of omeprazole with less side effects and better safety.

关 键 词：泮托拉唑 非食管静脉曲张 出血 疗效 

分 类 号：R969.4[医药卫生—药理学] R975.2[医药卫生—药学]