丹参酮ⅡA磺酸钠对急性心肌梗死溶栓后IMA、GPBB、CTNI水平的影响  

Tanshinone IIA Sodium Injection on Acute Myocardial Infarction After Thrombolytic Therapy to Effect for levels of IMA,GPBB,CTNI

作　　者：豆利华[1] 

机构地区：[1]河北省邢台市人民医院临床药学室

出　　处：《中国中医药现代远程教育》2010年第14期18-19,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的观察丹参酮ⅡA磺酸钠对急性心肌梗死溶栓后IMA、GPBB、CTNI水平的影响,探讨其在心肌缺血再灌注早期心肌保护作用。方法 80例患者随机分为治疗组和对照组;对照组给予溶栓及常规治疗,治疗组在对照组治疗基础上加用丹参酮ⅡA磺酸钠注射液静滴;采集患者静脉血,测定缺血性修饰白蛋白、糖原磷酸化酶同工酶BB、肌钙蛋白I进行各时点的比较。结果两组患者在入院时ACB值开始升高,在溶栓后达峰值,而后呈上升趋势,溶栓后12h基本恢复正常,治疗组ACB值明显高于对照组,差异有统计学意义（P〈0.05）;GPBB于溶栓后出现,4h达峰值,其后呈下降趋势;cTnI于溶栓后2h出现,其后呈上升趋势。治疗组于溶栓后及溶栓后2h、4h、6h、12h,GPBB、cTnI浓度均明显低于对照组。ACB、GPBB、cTnI浓度除在入院时比较,差异无统计学意义（P〉0.05）外,在溶栓后不同时点、组间以及组间和不同时点的交互作用中,差异均有统计学意义（P〈0.05）。结论丹参酮IIA磺酸钠对急性心肌梗死溶栓后心肌缺血再灌注损伤早期能够起到良好的保护作用。Objective To observe the Tanshinone IIA Sodium Injection on acute myocardial infarction after thrombolytic therapy to Effect for levels of IMA, GPBB, CTNI to explore in myocardial ischemia-reperfusion myocardial protection. Methods 80 patients were randomly divided into therapy group and control group; therapy group received thrombolytic therapy and conventional treatment were treated based on the use Tanshinone IIA Sodium Injection intravenous drip and the control group were only given received thrombolytic therapy and routine therapy~ venous blood samples were collected to determine ischemia modified albumin, glycogen phosphorylase isoenzyme BB, troponin I to the point of comparison. Results the ACB value began to increase in the admission, the peak after thrombolysis, then the rise, 12 hours after thrombolytic therapy returned to normal, the treatment group was significantly higher in ACB, the difference was statistically significant （P 〈0.05）; GPBB after thrombolysis, 4 hours, reached the peak, then decreased; cTnI at 2 hours after thrombolysis occurs, then the rise. therapy group on after thrombolysis and thrombolysis in 2 hours, 4 hours, 6 hours, 12 hours, GPBB, cTnI levels were significantly lower than the control group. ACB, GPBB, cTnI concentration in addition to the time of admission, the difference was not significant （P〉0.05）, the different time points after the thrombolytic therapy, groups, and groups, and different points of interaction, the differences were statistical Significance （P〈0.05）.Conclusion the Tanshinone IIA Sodium Injection in acute myocardial infarction after thrombolytic therapy in early myocardial ischemia-reperfusion injury can play a good protection. Keywords..

关 键 词：丹参酮 缺血早期心肌保护 缺血性修饰白蛋白 糖原磷酸化酶同工酶BB 

分 类 号：R285.5[医药卫生—中药学]