阿苯达唑分散片的制备及其溶出度测定  

Preparation and Dissolution Determination of Dispersible Albendazole Tablets

作　　者：邹映霞 谢虹虹[2] 

机构地区：[1]广州钢铁集团公司医院药剂科,510380 [2]广州中山大学附属第三医院药剂科,510630

出　　处：《中国中医药现代远程教育》2010年第14期209-210,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的制备阿苯达唑分散片,并考察其溶出度。方法以羧甲基淀粉钠（CMS-Na）、微晶纤维素（MCC）和聚维酮K30（PVP K30）为辅料,制备阿苯达唑分散片。选用转篮法进行溶出度考察,溶出量采用紫外分光光度法测定。结果分散片崩解时间小于3min,溶出参数分别为：T50=0.94min,Td=1.89min。结论阿苯达唑分散片质量能达到《中国药典》2005年版要求,分散片的溶出速度明显快于市售片。Objective To prepare dispersible albendazole tablets and to explore its dissolution. Methods Albendazole dispersible tablets was prepared with CMS-Na, MCC and polyvinylpyrrolidone K30（PVP K30） as supplementary materials. The dissolution ofalbendazole was measured using the basket method as well as UV-spectrophotometry. Results The disintegration of the dispersible albendazole tablets occurred within 3minutes. Other dissolution profiles were as follows： T50=0.94min, Td=1.89min. Conclusions The quality of the dispersible albendazole tablets meets China Pharmacopoeia（2005version） criteria, and the dissolution rate was faster than marketing albendazole tablets.

关 键 词：分散片 制备 阿苯达唑 溶出度 

分 类 号：R94[医药卫生—药剂学]