细菌溶解产物联合孟鲁司特钠对哮喘患儿血清免疫球蛋白、干扰素γ和白细胞介素4的影响及临床疗效分析  

Influence of bacterial lysates combined with montelukast sodium on serum immunoglobniin, interferon-γ and interleukin-4 in asthma and analysis of the clinical efficacy

作　　者：李温慈[1] 邵山鹰[1] 

机构地区：[1]温州医学院定理临床学院温州市第二人民医院儿科, 325000

出　　处：《中国医师进修杂志》2010年第22期4-6,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的观察细菌溶解产物（泛福舒）联合孟鲁司特钠对哮喘患儿血清免疫球蛋白、干扰素γ（IFN-γ）及白细胞介素4（IL4）的影响及临床疗效。方法对31例急性发作期哮喘患儿（研究组）在常规治疗的基础上加用泛福舒与盂鲁司特钠，连用3个月。观察治疗前后血清IgG、IgA、IgM、IFN-γ和IL4水平的变化，并与31例健康儿童（对照组）比较，同时观察研究组治疗前后日、夜间症状评分的变化。结果研究组治疗前IgG和IgA明显异常（p〈0．05），治疗后IgG和IgA均显著升高，但IgG仍然显著低于对照组，差异有统计学意义（P〈0．05）；治疗前IFN-γ，及IL-4均明显异常（P〈0．05），治疗后IFN-γ显著升高，IL-4则显著降低，差异均有统计学意义（P〈0．05）；治疗后，研究组日、夜间症状评分分别为（0．4±0．1）分和（0．7±0．2）分，均较治疗前的（2．6±0．3）分和（3．4±0．7）分显著下降，差异有统计学意义（P〈0．05）。结论哮喘患儿存在机体免疫功能下降，泛福舒联合孟鲁司特钠可有效控制其症状并改善机体免疫状态。Objective To observe the influence of bacterial lysates （broncho-vaxom） combined with montelukast sodium on serum immunoglobulin, interferon （IFN）-γ and interleukin （IL）-4 in asthma and the clinical efficacy. Methods Thirty-one patients with asthma in acute period of onset in children （study group） received broncho-vaxom combined with montelukast sodium for 3 months on the basis of conventional treatment. The changes of serum IgG, IgA, IgM, IFN-γ and IL-4 levels before and after treatment were observed and compared with 31 healthy children （control group）, the score changes of day and night symptom were also observed before and after treatment. Results IgG and IgA levels were abnormal significantly in study group before treatment （P 〈 0.05 ）, they were significantly increased after treatment, but IgG was still significantly lower than that in control group （P 〈 0.05 ）. IFN-γ and IL-4 were significantly abnormal in study group before treatment （P 〈 0.05）, IFN-γ was significantly increased after treatment （P 〈 0.05 ）, while IL-4 was significantly decreased （P 〈 0.05 ） ; after 3 months of treatment, the score of day and night symptom in study group were （0.4 ± 0.1 ） and （0.7 ± 0.2） scores respectively, which both decreased significantly than those before treatment [ （ 2.6 ±0.3 ） and （ 3.4 ± 0.7 ） scores respectively ], the difference were statistically significant（P 〈 0.05 ）. Conclusion Children with asthma have the existence of decreased immune function, application of broncho-vaxom combined with montelukast sodium can effectively control its symptoms and improve immune status.

关 键 词：免疫球蛋白类 干扰素Ⅱ型 白细胞介素4 细菌溶解产物 孟鲁司特 

分 类 号：R725.6[医药卫生—儿科]