血浆D-二聚体的检测和血气分析在慢性阻塞性肺疾病中的相关性探讨  

作　　者：张静[1] 刘庆玲[2] 熊德栋[1] 张辉[3] 

机构地区：[1]山东省滨州市中心医院检验科,251700 [2]淄博市妇幼保健院检验科,255029 [3]山东省滨州市中心医院重症监护室,251700

出　　处：《中国医疗前沿》2010年第16期73-73,8,共2页China Healthcare Innovation

摘　　要：目的探讨慢性阻塞性肺疾病(COPO)患者血浆D-二聚体检测的临床意义及与血气分析的相关性。方法对30例COPD患者治疗前后血浆D-二聚体、血气分析及20例对照组分别进行测定。结果血浆D-二聚体在COPD加重期患者明显增高,与对照组相比有显著性差异。血浆D-二聚体与血氧分压(PaO2)呈负相关,而与二氧化碳分压(PaCO2)呈正相关。结论血浆D-二聚体可作为COPD急性期反应的指标,低氧血症、高碳酸血症与其增高密切相关。在COPD患者的病情监测及预后中具有重要意义。Objective To study the change of D-dimmer and correlatlon of them with blood gas analysis in patients with Chronic obstructive pulmonarydisease. Methods The D-dimer level were measured in 30 patients with Chronic obstructive pulmonarydisease and in 20 healthy controls. Blood gas analysis was measured in 30 patients with Chronic obstructive pulmonarydisease respirationfailure. Results The D-dimmer were significandy higher in exacerbate patients than in controls; The D-dimer level were negativly correlated with PaO2, but they were positively correlated with PaCO2. Conclusions The elevated D-dimer level may be associated with hypercoaglflability state of Chronic obstructive pulmonarydisease and contributes to thrombi in small pulmonary arteries and arterioles. Hypoxemia and hypercapnia were correlated with hypereoagulahility state.

关 键 词：慢性阻塞性肺疾病 D-二聚体 血气分析 

分 类 号：R446.11[医药卫生—诊断学]