DCC/DMAP催化制备乙酰阿魏酸苯丙醇酯  

DCC/DMAP catalyze to synthesize Phenylpropanol ester of acetyl ferulic acid

作　　者：张春桃[1] 卢茂芳[1] 刘恒言[2] 

机构地区：[1]湖南中医药大学有机药化教研室,410208 [2]湖南中医药大学,2005级药学本科410208

出　　处：《中国实用医药》2010年第23期37-38,共2页China Practical Medicine

摘　　要：目的改进乙酰阿魏酸苯丙醇酯的合成工艺。方法以N,N-二环己基碳二亚胺(DCC)和4-二甲胺基吡啶(DMAP)为催化剂,以乙酰阿魏酸和1-苯丙醇(又名利胆醇)在室温下制备乙酰阿魏酸苯丙醇酯。结果该方法反应条件比较温和,均可合成乙酰阿魏酸苯丙醇酯,DCC/DMAP法反应3h,产率73.4%。结论以DCC/DMAP法合成乙酰阿魏酸苯丙醇酯,反应时间更短、收率更高。Objective To improve synthetic technics of Phenylpropanol ester of acetyl ferulic acid. Methods Using dicyclohexyl carbodiimide （ DCC） and 4-dime-thylamino pyridine （ DMAP） as catalyzer,acetyl ferulic acid and 1-Phenylpropanol （ also known as cholagogic alcohol） as raw materials,at room temperature to synthesize Phenylpropanol ester of acetyl ferulic acid. Results This synthetic technics are relatively mild,Phenylpropanol ester of acetyl ferulic acid can be synthesized,DCC/DMAP method react 3 h,the yield is 73. 4%. Conclusion Using DCC/DMAP method to synthesize Phenylpropanol ester of acetyl ferulic acid,the reactive time is shoter and the yield is higher.

关 键 词：乙酰阿魏酸苯丙醇酯 DCC/DMAP法 催化 

分 类 号：TQ463[化学工程—制药化工]