具有生物活性的scalarane型二倍半萜类海洋天然产物的研究进展  

Research advances in the biologically active scalarane sesterterpenoid marine natural products

作　　者：刘洋[1] 王正林[1] 孟祥见[1] 樊文元[1] 杜文婷[1] 邓卫平[1] 

机构地区：[1]华东理工大学药学院,上海200237

出　　处：《中国药科大学学报》2010年第4期289-298,共10页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.20972047);上海市曙光人才计划资助项目(No.09SG28)~~

摘　　要：大多数scalarane型二倍半萜类海洋天然产物具有较好的抗肿瘤和抗结核病的药理活性。因此,越来越多的研究人员致力于此类化合物的合成研究,并取得了一定的进展。本文对此类化合物的研究背景、生物药理活性以及最新的合成进展进行介绍和综述,并对其研究前景进行展望。The majority of scalarane sesterterpenoid marine natural products exhibit good biological activities against cancers and tuberculosis. As a consequence,more and more researchers have paid great attention to their synthesis and have made some progress. In this review,the research background,the biological activities and synthesis,as well as the prospect of scalarane sesterterpenoids are presented.

关 键 词：scalarane型二倍半萜类 海洋天然产物 药理活性 合成 

分 类 号：R282[医药卫生—中药学]