抗结核药物的研究进展  

Advances in the research of anti-tuberculosis drugs

作　　者：王天才[1] 周金培[1] 张惠斌[1] 

机构地区：[1]中国药科大学新药研究中心,南京210009

出　　处：《中国药科大学学报》2010年第4期299-305,共7页Journal of China Pharmaceutical University

基　　金：国家"重大新药创制"科技重大专项资助项目(No.2009ZX09103-094);国家自然科学基金资助项目(No.30973638)~~

摘　　要：近年来,每年约有180万人死于结核病,结核病已经成为全球性的公众健康问题。耐药结核杆菌的出现和结核艾滋病双重感染已成为结核病治疗的主要挑战。因此,研制新的抗结核药物显得尤为迫切。鉴于如此迫切形势,研究人员专注于抗结核药物的研发,发现了许多具有抗结核菌活性的候选药物,其中有一些已经进入临床试验。本文对几类新型抗结核药物的化学结构、作用机制、构效关系、代谢、抗结核活性以及临床应用进行了综述。Tuberculosis is increasingly becoming a major health problem worldwide,with approximately 1. 8 million people dying annually from the disease. The emergence of drug resistant strains and HIV /TB co-infection has been the major challenge to the treatment of tuberculosis. Thus,it is urgent to develop new potential anti-tuberculosis （ anti-TB） drugs. Given the present situation,researchers increasingly focused on the RD of anti-TB drugs and discovered many active candidates with good potential,some of which have entered clinical trials. This review summarized the structures,mechanism of action,structure-activity relationships,activity and clinical applications of several new class of anti-TB drugs.

关 键 词：抗结核药物 临床试验 耐药性 构效关系 

分 类 号：R978.3[医药卫生—药品] R521[医药卫生—药学]