巯亚硝基卡托普利的抗高血压效应  

S nitrosocaptopril preferentially decrease diastolic pressure in hypertensive models

作　　者：林默君[1] 杨歆萍[1] 王晶[1] 贾秉钧[1] 贾力[1] 

机构地区：[1]福建医科大学生理学教研室

出　　处：《中国药理学通报》1999年第1期73-76,共4页Chinese Pharmacological Bulletin

基　　金：福建省卫生厅资金资助

摘　　要：目的观察巯亚硝基卡托普利（ＣａｐＮＯ）对不同类型高血压大鼠血压的影响并与卡托普利（Ｃａｐ）相比较。方法记录麻醉和清醒大鼠颈动脉血压。结果ＣａｐＮＯ对正常大鼠、急性二肾一夹高血压大鼠；自发性高血压大鼠均表现明显的剂量依赖性的降压效应，且强于同剂量Ｃａｐ。其特点表现早、快、强而持久，加速降压速率，延长降压时程、增大降压曲线面积，尤其对舒张压的降压影响更显著于对收缩压的影响，上述作用在高血压动物的表现均较正常血压动物更明显。结论ＣａｐＮＯ抗高血压作用优于Ｃａｐ，其对舒张压的作用强于对收缩压的影响。AIM To compare antihypertensive effects of S nitrosocaptopril (CapNO) and Captopril in hypertensive models. METHODS Measurements of cartoic arterial pressure were carried out in either anesthetized or awake rats. RESULTS CapNO produced dosedependent antihypertensive effects in anesthetized normative, acute two kidney one clipped rats and awake spontancously hypertensive rats. CapNO showed a fast set up, a prolonged time course and a large area of depressor curve in decreasing blood pressure. The inhibition of diastolic pressure by CapNO was more prominent than Cap. CapNO preferentially inhibited the diastolic pressure, and the depressor effects of CapNO were more potent in hypertensive rats than in normative rats. CONCLUSION CapNO preferentially inhibits diastolic pressure in various hypertensive rats and the hypotensive effects of CapNO are potent than that of Cap.

关 键 词：疏亚硝基 卡托普利 降压效应 降压药 

分 类 号：R972.4[医药卫生—药品]