谷氨酸注入下丘脑的背内侧核引起升压反应的机制  

Mechanisms underlying pressor response of nucleus dorsomedialis hypothalami to glutamate

作　　者：丁欣[1] 吴金胜[1] 顾蕴辉[1] 王益光 谭璐 

机构地区：[1]北京医科大学生理学系

出　　处：《北京医科大学学报》1999年第2期124-126,共3页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金!（３９１７０８９９）;卫生部科学研究基金!（９１５０１３５４）

摘　　要：分析下丘脑背内侧核升压反应的机制。方法；大鼠脑内或静脉注射不同药物，记录血压和心率的变化。结果：（１）谷氨酸注入ＮＤＭ，Ｐ物质注入室旁核或延髓头端腹个侧区均引起升压反应；（２）ＮＤＭ升压反应可被双侧ＮＰＶ或ＲＶＬ内注入Ｐ物质拮抗剂衰减，但ＲＶＬ内注入阿托品无此效应；（３）静脉注射酚妥拉明也能使ＮＤＭ升压反应减小，而心得安或甲基阿托品静静脉注射对该反应影响。To analyse mechanisms underlying pressor response of nucleus dorsomedialis hypothalami (NDM). Methods: Effects of different drugs delivered by intra-brain or i. v. injections on blood pressure and heart rate. Results: (1)Excitation of the NDM by glutamate, substance P (SP) injection into nucleus paraventricularis (NPV) or rostral ventrolateral medulla (RVL) all induced pressor responses. (2) The NDM pressor response could be attenuated by pre-injection of SP antagonist into NPV or RVL, but RVL pre-treatment with atropine had no such effect. (3) phentolamine (i. v. ) also reduced the NDM pressor response, but propranolol or methyl atropine (i. v.) did not. Conclusion: The NDM pressor response is mediated by the NPV (SP receptor)and RVL (SP receptor)-sympathetic vasoconstrictor nerve system.

关 键 词：P物质 下丘脑 背内侧核 血压 谷氨酸 

分 类 号：R338.27[医药卫生—人体生理学]