早期SANFH大鼠骨组织中CGRP免疫阳性神经纤维的变化及意义  

Experimental study on changes of CGRP-immunoreactive positive nerve fibers innervation in bone tissue of ratsand its significance

作　　者：卢政好[1] 詹瑞森[2] 孙双喜[1] 龙雄武[1] 杨驰[1] 陈世杰[1] 

机构地区：[1]南华大学附属南华医院骨科,湖南省衡阳421002 [2]中南大学湘雅三医院骨科

出　　处：《中国医师杂志》2010年第7期872-875,共4页Journal of Chinese Physician

摘　　要：目的 观察降钙素基因相关肽（CGRP）免疫阳性神经纤维在早期激素性股骨头缺血坏死（SANFH）骨组织中的变化,并探讨其意义.方法 采用大剂量冲击造模方法,造成SD大鼠SANFH模型.应用免疫组织化学技术光镜下观察CGRP免疫阳性神经纤维在SANFH负重区骨组织中的变化规律.结果 股骨头软骨下骨髓腔内CGRP免疫阳性神经纤维的数目先增多,后减少（第6周达高峰,为10.28±0.66）,均较正常组增多,差异有统计学意义（P＜0.01）.结论 （1）CGRP免疫阳性神经纤维在激素性股骨头缺血坏死组织中的分布发生变化;（2）CGRP免疫阳性神经纤维参与激素性股骨头缺血坏死后的修复过程.Objective To observe the changes of calcitonin gene-related peptide（CGRP） -immunoreactive positive nerve fibers innervation in bone tissue of femoral heads during the pathological process of early steroid-induced avascular necrosis of the femoral head （SANFH）, and explore its significance.Methpathological group of SANFH was induced.Immunohistochemical technique was used and the changes of CGRP-immunoreactive positive nerve fibers innervation in weight bearing area of the femoral heads during the pathological process of early SANFH were observed.Result The number of CGRP-immunoreactive nerves increased first and then decreased （ Peaked at 6 weeks, 10.28 ± 0.66 ）, but it was more than that ofnormal control group.There was significant difference between two groups （ P ＜ 0.01 ）.Conclusion There were changes in the distribution of CGRP-immunoreactive positive nerves fiber during the process of bone repair after SANFH.CGRP-immunoreactive positive nerves fiber might take part in the process of bone repair in SANFH.

关 键 词：股骨头坏死/代谢/免疫学/化学诱导 降钙素基因相关肽/代谢/免疫学 神经纤维/代谢/免疫学 激素类/副作用 

分 类 号：R681.8[医药卫生—骨科学]