高血压与颈动脉粥样硬化斑块的关系探讨  

Relationship between hypertension and carotid atherosclerotic plaque

作　　者：文芳梅[1] 严建宇[2] 冯媛媛[1] 张艳敏[1] 

机构地区：[1]新疆维吾尔自治区人民医院干保一科,新疆乌鲁木齐市830001 [2]武警新疆总队医院

出　　处：《心血管康复医学杂志》2010年第4期394-396,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：探讨原发性高血压患者颈动脉粥样硬化斑块与高血压分级、脉压的关系.方法：选择原发性高血压患者160例（高血压1级46例、2级56例、3级58例）,43例健康体检者作为健康对照组,测量血压、血清超敏C反应蛋白（hs-CRP）、纤维蛋白原、血脂并行颈部血管B超检查;同时根据脉压,160例原发性高血压患者被分成3组,比较三组间颈动脉血管B超检查结果.结果：①各高血压亚组血清hs-CRP水平[1级（1.90±3.34]mg/L）,2级 （2.50±2.39）mg/L, 3级（12.00±35.76）mg/L]明显高于健康对照组（1.77±2.80）mg/L,逐级比较差异有显著性（P〈0.05-〈0.001）;②各高血压亚组颈动脉粥样硬化斑块的发生率（1级：50.00%, 2级：53.57%,3级：86.21%）明显高于正常对照组（25.58%,P均〈0.001）, 逐级比较差异有显著性（P〈0.05-〈0.001）;③随着高血压患者脉压的增大,颈动脉粥样硬化斑块的发生率明显增加（33.33%∶ 62.16%∶83.93%, P均〈0.001）.结论：高血压和脉压是颈动脉粥样硬化斑块发生率增高的危险因素.Objective： To investigate the relationship among stage of hypertension, pulse pressure and incidence of carotid atherosclerotic plaque. Methods： A total of 160 patients with essential hypertension （EH） were divided into three groups according to the stage （stage 1 46 cases, stage 2 56 cases, stage 3 58 cases）, 43 healthy persons were regard as normal control group. Doppler and two dimensional ultrasound examination were performed, and blood pressure, the serum high sensitive C-reaction protein （hs-CRP） , fibrinogen and serum lipid were measured in each group. The 160 EH patients also were divided into three groups （A, B, and C） according to the pulse pressure and compared the incidence of carotid atherosclerotic plaque with normal control group. Results： OThe hs-CRP in EH groups [stage 1 （1.90±3.34） mg/L, stage 2 （2.50±2.39） mg/L, stage 3 （12.00± 35.76） mg/L）] was higher than that of normal control group （1.77 ± 2.80） rag/L, and compared between groups one by one had significant difference （P〈0. 05-〈0. 001） ; （2）The incidence of carotid atherosclerotic plaque in EH groups （stage 1 50.00%, stage 2 53.57, stage 3 86.21%） was higher than that of normal control group （25.58% , P〈0. 001） ; and compared between groups one by one had significant difference （P〈0. 05-0. 001）; （3）The incidence of carotid atherosclerotic plaque elevated with increasing pulse pressure gradually and among three groups （pulse pressure： group A 40 mmHg, group B 41-59 mmHg, group C ≥60 mmHg） had significant difference （group A 33.33% vs. group B 62.16% vs. group C 83. 93%, P〈0. 001 respectively）. Conclusion： The stage of hypertension and pulse pressure are risk factors of carotid athcrosclerotic plaque

关 键 词：高血压 颈动脉疾病 血压 

分 类 号：R544.109[医药卫生—心血管疾病]