中药联合聚乙二醇干扰素α-2a治疗慢性丙型肝炎疗效观察  

Clinical observation of combined Chinese medicine and pegylated interferon α-2a in treating chronic hepatitis C

作　　者：敬小华[1] 祁培宏[1] 张永霞[1] 董建宁[1] 李艳君[1] 董雪莲[1] 裴启福[1] 

机构地区：[1]青海省中医院肝胆科,青海西宁810000

出　　处：《上海中医药杂志》2010年第8期36-37,53,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：目的观察中药联合聚乙二醇干扰素α-2a治疗慢性丙型肝炎的临床疗效。方法将48例慢性丙型肝炎患者随机分为治疗组26例和对照组22例。对照组采用综合保肝、支持、对症等治疗措施,并予聚乙二醇干扰素α-2a皮下注射及利巴韦林口服,治疗组在此基础上加服中药;两组均治疗48周,观察临床疗效及治疗后肝功能、丙型肝炎病毒RNA(HCV-RNA)变化情况。结果治疗组、对照组总有效率分别为88.5%和86.4%,组间疗效差异无统计学意义(P>0.05);两组治疗后肝功能均较治疗前明显改善(P<0.05),组间治疗后差异有统计学意义(P<0.05);两组治疗后HCV-RNA定量均较治疗前明显下降(P<0.05),组间治疗后差异无统计学意义(P>0.05);治疗组不良反应明显少于对照组(P<0.05)。结论中药联合聚乙二醇干扰素α-2a治疗慢性丙型肝炎的疗效较好,不良反应发生率低。Objective To observe the clinical effect of combined Chinese medicine and pegylated interferon α-2a in the treatment of chronic hepatitis C.Methods Forty-eight cases were randomly divided into two gorups： control group in which 22 cases were treated with routine modality and treatment group in which 26 cases were treated with routine modality and Chinese Medicine.After 48-week treatments,the clinical efficacy,liver function and hepatitis C virus RNA（HCV-RNA） were observed.Results The total effective rate was 88.5% in the treatment group and 86.4% in the control group,with no significant difference between the two groups（P〈0.05）.After treatment,liver function improved significantly in both groups（P〈0.05）,with a difference between the two groups（P〈0.05）;the amount of HCV-RNA was significantly reduced in both groups（P〈0.05）,with no significant difference between the two groups（P〈0.05）.The adverse reaction was significantly less in the treatment group than in the control group（P〈0.05）.Conclusion Combined Chinese medicine plus pegylated interferon α-2a is quite effective in the treatment of chronic hepatitis C,with less adverse reaction.

关 键 词：慢性丙型肝炎 中西医结合疗法 聚乙二醇干扰素Α-2A 

分 类 号：R512.63[医药卫生—内科学]