康乐三号方结合西药治疗气阴两虚络脉瘀阻型糖尿病肾病30例  

Treatment of 30 cases of diabetic nephropathy of qi-yin deficiency and blood stasis by "Kangle-Ⅲ Decoction" and western medicine

作　　者：孙爱英[1] 刘珍[1] 刘静[1] 曾旭[1] 

机构地区：[1]邵阳医学高等专科学校附属医院内一科,湖南邵阳422000

出　　处：《上海中医药杂志》2010年第8期38-40,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：湖南省邵阳市科技局资助项目(Z0903)

摘　　要：目的观察康乐三号方结合西药治疗气阴两虚、络脉瘀阻型糖尿病肾病的临床疗效。方法将60例糖尿病肾病患者随机分为治疗组和对照组各30例,两组均予糖尿病基础治疗,治疗组同时加服康乐三号方。两组疗程均为4周,观察临床疗效、中医证候疗效及治疗后尿白蛋白排泄率、肾功能、血糖、血脂等指标的变化情况。结果治疗组临床总有效率为76.67%,中医证候总有效率90.00%,对照组分别为50.00%和46.67%;组间临床疗效、中医证候疗效比较,差异均有统计学意义(P<0.05)。治疗组治疗前后比较,UAER、Scr、BUN、2hPG、FBG、TC、TG差异均有统计学意义(P<0.05);对照组治疗前后比较,Scr、FBG差异有统计学意义(P<0.05)。组间治疗后比较,UAER、Scr、BUN、TC、TG差异有统计学意义(P<0.05,P<0.01)。结论康乐三号方结合西药治疗气阴两虚、络脉瘀阻型糖尿病肾病疗效确切。Objective To observe the clinical efficacy of ＂Kangle-Ⅲ Decoction＂ and western medicine in the treatment of diabetic nephropathy of qi-yin deficiency and blood stasis.Methods Sixty cases were randomized into two groups： treatment group in which 30 cases were treated with routine therapy and ＂Kangle-Ⅲ Decoction＂,and control group in which 30 cases were treated with routine therapy alone,with a course of four weeks.The clinical efficacy,syndrome effect,the contents of urinary albumin excretion（UAER）,serum creatinine（Scr）,fasting blood sugar（FBG）,total cholesterol（TC） and triglycerides（TG） were observed.Results The total effective rates of clinical efficacy and syndrome effect were respectively 76.67% and 90.00% in the treatment group,and 50.00% and 46.67% in the control group,with differences between the two groups（P〈0.05）.After treatment,the UAER,Scr,BUN,24hPG,FBG,TC and TG were all improved in the treatment group（P〈0.05）,while only the Scr and FBG were improved in the control group（P〈0.05）;there were striking differences in the contents of UAER,Scr,BUN,TC and TG between the two groups（P〈0.05,P〈0.01）.Conclusion ＂Kangle-Ⅲ Decoction＂ and western medicine is quite effective for diabetic nephropathy of qi-yin deficiency and blood stasis.

关 键 词：糖尿病肾病 气阴两虚 络脉瘀阻 中西医结合疗法 康乐三号方 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]