P(NIPA-co-NVP)温敏性凝胶微粒的药物释放与降解  

Drug releasing and degradability of thermo-sensitive micro-spheres of poly(N-isopropylacrylamide-co-N-vinyl-2-pyrrolidone) hydrogel

作　　者：徐建[1] 张睿[1] 何江川[1] 

机构地区：[1]北京联合大学生物化学工程学院生物医药系,北京100023

出　　处：《化学研究与应用》2010年第8期1015-1020,共6页Chemical Research and Application

基　　金：北京市教委科技发展面上项目(KM201011417007)

摘　　要：本文采用N-异丙基丙烯酰胺(NIPA)与N-乙烯基吡咯烷酮(NVP),以N,N-亚甲基双丙烯酰胺(MBA)为交联剂,氧化-还原试剂引发,通过反相悬浮共聚制备了微粒状热缩温敏水凝胶;研究了共聚单体配比及交联剂用量对凝胶温敏性能和溶胀性能的影响,并利用其温敏性以水杨酸为模型药物进行了药物吸附-释放实验;利用红外光谱和显微技术对微凝胶的结构和形态进行了表征,并初步探讨了该凝胶降解的可能性。实验发现:NVP单体的加入使共聚凝胶的体积相变温度和平衡溶胀率都明显升高,药物吸附率增加,而溶胀-退溶胀的响应速度及水保留率降低,释药率降低;该凝胶在pH1,37℃条件下能够降解,降解率随单体中NVP含量的增加而增加,随交联剂用量的增加而降低。N-isopropylacrylamide（NIPA） and N-vinyl-2-pyrrolidone（NVP） were copolymerized with N,N-methyl biacrylamide（MBA） as crosslinking agent and peroxides as initiator,and thermo-shrinkable micro-spheres of hydrogels were obtained through an inverse suspension polymerization.Effects of co-monomers ratio and amount of crosslinking agent on sensitivity and swelling property of the gels were investigated,and drug adsorption/releasing ability of the gels were determined.The structure and morphology of the micro-spheres were probed through IR and microscope.The degradability of the gels was also surveyed.It was found that copolymerization with NVP results in increase of LCST,swelling ratio and drug adsorption of the gels,while swelling/deswelling was delayed and drug releasing ratio decreased.The gels could degrade in buffer solution of pH1 at 37℃,and the degradation conversion increased with the increasing of NVP amount while decreased with the increasing of crosslinking agent amount.

关 键 词：NIPA NVP 粒状水凝胶 温度敏感 药物释放 降解 

分 类 号：O632.4[理学—高分子化学]