(5S,6R)-2-(4-甲基)苯基-6-[(1R)-叔丁基二甲基硅氧乙基]-青霉烯-3-羧酸乙酯的合成研究  

Synthesis of ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethyl]-penem-3-carboxylate

作　　者：杨静[1] 章文军[1] 郭磊[1] 

机构地区：[1]河北工业大学化工学院,天津300130

出　　处：《化学研究与应用》2010年第8期1054-1057,共4页Chemical Research and Application

基　　金：河北省自然科学基金资助项目(B2005000007)

摘　　要：A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.A compound ethyl（5S,6R）-2-（4-methylphenyl）-6-[（1R）-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material（3R,4R）-3-[（1R）-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none（4AA）upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.

关 键 词：青霉烯 4AA (5S 6R)-2-(4-甲基)苯基-6-[(1R)-叔丁基二甲基硅氧乙基]-青霉烯-3-羧酸乙酯 合成 

分 类 号：O623.624[理学—有机化学]