体外循环管道表面改性的回顾与进展  

Review and Progress in Surface Modification of Cardiopulmonary Bypass Circuits

作　　者：罗鹏[1] 杨剑[1] 刘维永[1] 

机构地区：[1]第四军医大学附属西京医院心血管外科,西安710032

出　　处：《中国生物医学工程学报》2010年第4期614-618,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30700174)

摘　　要：体外循环是目前心脏外科的一项常规技术,但由于制备体外循环管道所使用的人工材料的生物相容性欠佳,体外循环往往可导致患者术后严重的全身炎症反应,从而影响其临床转归。为减小体外循环的这一不良影响,多种策略得到发展,体外循环管道的表面改性就是其中一种改善其生物相容性最行之有效的方法。文中对目前体外循环管道表面改性的几种主要方法,如生物活性表面、生物惰性表面和生物模仿表面等的原理及其临床应用做一回顾,并介绍了其最新研究进展。Currently,cardiopulmonary bypass（CPB） is a routine technique in cardiac surgery.However,due to the poor biocompatibility of artificial materials used in CPB circuits,serious systemic inflammatory response may occur in patients with cardiac surgery under CPB,and thus affects clinical outcomes.A number of strategies have evolved over the past years to minimize this unwanted sequelae of CPB,and surface modification is one of the most feasible and effective approach for improving the biocompatibility of CPB circuits.This paper reviewed several main methods of surface modification for CPB circuits such as bioactive surface,bioinert surface and biomimetic surface,and their clinical applications.Their recent advance was presented as well.

关 键 词：体外循环管道 表面改性 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]