高血压人群伴发代谢紊乱的现状及特点  

The Status and Characteristics of Hypertension Patients with Metabolic disorder

作　　者：刘伟芳[1] 陈利强[1] 邹慧英[1] 吴伟琼[1] 许美伦[1] 温红[1] 吕汉文[1] 

机构地区：[1]广东省惠州市中心人民医院,516001

出　　处：《中国医药指南》2010年第24期5-7,共3页Guide of China Medicine

基　　金：广东省惠州市科技计划项目(2007Y014)

摘　　要：目的观察高血压合并代谢紊乱的状况及其对靶器官损害的特点。方法住院高血压1032例分为单纯性高血压组147例,高血压并肥胖组110例,高血压并血脂紊乱组154例,高血压并糖尿病组(DM组)160例,高血压并代谢综合征组(MS组)461例,观测各组临床和生化指标,调查心脑肾及外周血管病变的发生率,并将各组资料对比分析。结果①住院高血压患者中单纯性高血压仅为14.3%,85.7%的高血压患者合并有代谢紊乱。②高血压合并肥胖、高血压合并血脂紊乱、高血压合并DM、高血压合并MS时,肾病、心血管病、脑血管病的发生率较单纯性高血压明显增高(P<0.01)。高血压并肥胖、高血压并MS时,脑血管病的发生率较其他3组明显增高(P<0.01)。高血压合并血脂紊乱、高血压合并DM、高血压合并MS时,外周血管病变发生率较其他两组明显增高(P<0.05或P<0.01)。高血压合并MS时,其肾病、心血管病、脑血管病、外周血管病变的发生率最高(P<0.01)。③高血压合并DM、高血压合并MS时,其FINS、HOMA-IR较其他3组显著升高(P<0.01)。结论住院高血压患者约有4/5合并有代谢紊乱。高血压合并单因素代谢异常时,将增加心脑肾血管病变的发生率;高血压合并代谢综合征时,对心脑肾血管病变影响更大,其胰岛素抵抗更明显。Objective To observe the status of hypertension with metabolic disorders and the characteristics of target organ damage. Methods 1032 cases of hypertension patient group is divided into 147 patients with simple hypertension, high blood pressure and obesity group of 110 patients with hypertension and lipid disorder group, 154 cases of hypertension and diabetes mellitus group （DM group） 160 patients with hypertension and metabolic Syndrome group （MS group） 461 patients, observation of clinical and biochemical parameters in each group to investigate the mind, brain and kidney and the incidence of peripheral vascular disease, and each set of data analyzed. Results ①Simple hypertension in hospitalized patients with hypertension compared with 14.3%, 85.7% of hypertensive patients with metabolic disorders. ②Hypertension with obesity, hypertension dyslipidemia, hypertension with DM, hypertension with MS, the kidney disease, cardiovascular disease, cerebrovascular disease incidence was signifi cantly higher compared with simple hypertension （P〈0.01）. Hypertension and obesity, hypertension and MS, the incidence of cerebrovascular disease was signifi cantly higher than the other three groups （P〈0.01）. Hypertension with dyslipidemia, hypertension with DM, hypertension with MS, the incidence of peripheral vascular disease was signifi cantly higher than the other two groups （P〈0.05 or P〈0.01）. Hypertension with MS, their kidney disease, cardiovascular disease, cerebrovascular disease, peripheral vascular disease of highest incidence （P〈0.01）. ③Hypertension with DM, hypertension MS, its FINS, HOMA-IR than the other three groups were signifi cantly higher （P〈0.01）. Conclusion Hypertensive patients hospitalized about 4 / 5 associated with metabolic disorders. Single factor metabolic disorders with hypertension, the heart, brain and kidney to increase the incidence of vascular disease; hypertension with metabolic syndrome, renal vascular lesions on the heart and brain a greater impact,

关 键 词：高血压 代谢因素 靶器官损害 

分 类 号：R544.1[医药卫生—心血管疾病]