HIV阳性人群合并弓形虫感染现况调查  

Survey on coinfection with Toxoplasma and HIV among rural people in China

作　　者：田利光[1] 程国金[2] 陈家旭[1] 郭俭[1] 童小妹[1] 蔡玉春[1] 刘琴[1] 周晓农[1] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所,上海200025 [2]安徽省阜阳市疾病预防控制中心

出　　处：《中国血吸虫病防治杂志》2010年第4期368-370,共3页Chinese Journal of Schistosomiasis Control

基　　金：科技部重大支撑专项(2003DIA6N009;2005DKA21104;2007BAC03A02);国家科技重大专项(2008ZX10004-011)

摘　　要：目的了解我国农村地区HIV阳性人群合并弓形虫感染现状,以及合并感染与CD4+T淋巴细胞的关系。方法按1:1匹配的方式,在现场招募HIV阳性感染者和HIV阴性对照624人作为研究对象,采集其外周血样本,采用ELISA法检测弓形虫抗体,并检测其体内CD4+T淋巴细胞水平。结果共对604人同时进行了弓形虫抗体和CD4+T淋巴细胞水平检测,HIV阳性人群弓形虫抗体阳性率为1.32%,阴性对照人群弓形虫抗体阳性率为0.33%,两者差异无统计学意义(P>0.05)。HIV阳性感染者中,合并和未合并弓形虫感染者体内CD4+T淋巴细胞水平分别为(446.75±177.25)个/μl和(413.55±243.37)个/μl,两者差异无统计学意义。结论当地一般人群和HIV阳性人群弓形虫感染率均较低,弓形虫感染与HIV阳性人群体内CD4+T淋巴细胞水平之间的关系有待进一步研究。Objective To investigate the status of coinfection with Toxoplasma and HIV in rural area,China.Methods In according to a 1：1 match,a total of 624 cases and controls were recruited as subjects.The blood samples were collected to test Toxoplasma infection using the ELISA method,and CD4＋T cell counts were also determined.Results The Toxoplasma infection rates of HIV positive-people and control people were 1.32% and 0.33%,respectively.Among the HIV positive people,CD4＋T cell counts of the people with HIV/Toxoplasma coinfection were （446.75±177.25）/μl,and the CD4^＋T cell counts were （413.99±242.42）/μl in the people without Toxoplasma infection,there was no significant difference between them.Conclusions There are lower infection rates of Toxoplasma among the people with or without HIV infection.There is no significant relationship between CD4＋T cell counts and the infection of Toxoplasma among the HIV-positive people.

关 键 词：HIV感染 弓形虫 合并感染 现况调查 

分 类 号：R512.91[医药卫生—内科学] R382.5[医药卫生—临床医学]