Th1/Th2极化相关因子在血吸虫病肝纤维化发生发展中的作用  

Effect of polarization of Th1/Th2 related factors in process of schistosomiasis hepatic fibrosis

作　　者：王瑜[1,2] 夏超明[1] 

机构地区：[1]苏州大学医学部病原生物学系,苏州215123 [2]安徽理工大学医学院

出　　处：《中国血吸虫病防治杂志》2010年第4期384-387,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家自然科学基金(30772027)

摘　　要：血吸虫病肝纤维化是宿主感染血吸虫后发生免疫反应导致的严重病理损害。宿主处于何种免疫应答状态决定了肝纤维化的进展。当宿主体内以Th1免疫应答为主时,不易发生肝纤维化;而宿主体内以Th2免疫应答为主时,易形成肝纤维化。细胞因子及共刺激分子在Th1/Th2极化过程中均发挥重要的作用。本文综述了细胞因子和共刺激分子调控Th1/Th2极化的作用及其与血吸虫病肝纤维化发生、发展相关性的研究进展。The morbidity of chronic schistosomiasis in host is characterized by a marked egg-induced CD4＋T-cell programmed cumulative hepatic fibrosis.It is not easy to form hepatic fibrosis in host when immune response is Th1-polarized.If immune response is Th2-polarized,the formation of hepatic fibrosis is common.Cytokines and costimulatory molecules play key roles in Th1/Th2 polarization,this paper reviews the effect of cytokines and costimulatory molecules on regulating Th1/Th2 polarization and their relation to schistosomiasis hepatic fibrosis.

关 键 词：血吸虫病 TH1/TH2极化 肝纤维化 

分 类 号：R532.21[医药卫生—内科学]