血糖水平与超敏C反应蛋白及颈动脉内膜的关系  

The relationship between the level of blood glucose and C-reactive protein level and carotid intimid medial thickness

作　　者：高历男[1] 王文清[2] 李玲[2] 徐丽梅[2] 李燕玉[2] 李丰[2] 

机构地区：[1]解放军总参谋部警卫局保健处,北京100017 [2]空军总医院

出　　处：《中国临床保健杂志》2010年第4期347-349,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨糖代谢和炎性反应与动脉硬化的关系。方法将180例患者通过糖耐量试验分为血糖正常组、糖耐量异常组及2型糖尿病(T2DM)组;每组60例,严格禁食10h后空腹采血,行超敏C反应蛋白(CRP)、一氧化氮(NO)、空腹胰岛素(FIns)及高密度脂蛋白-胆固醇(HDL-C)水平检测及颈动脉内膜—中层厚度(IMT)测定。结果随着血糖异常逐渐加重,超敏CRP逐渐增高,NO、HDL-C及FIns水平呈下降趋势,IMT明显增厚(P<0.05)。结论随着糖代谢异常的加重,体内炎性反应及动脉硬化程度逐渐加重。Objective To investigate the relationship between the level of blood glucose and C-reactive protein,carotid intimal medial thickness and compare with blood nitrie oxide （ NO） ,insulin （ FIns） and HDL-C. Methods 180 patients enrolled in our study were divided into three groups,which were normal glucosetolerance,abnormal glucose tolerance and type 2 diabetes,and plasma CRP,NO,FIns,HDL-C and IMT were measured. Results The Plasma CRP and IMT was increasesd gradually with blood glucose increased,whereas the level of NO,FIns,HDL-C was decreasesd respectively. Conclusion Vascular endothelial damage and inflammation are related to the alonormal glucose metabolism.

关 键 词：糖尿病 2型 葡糖耐量不良 C反应蛋白质 血管内膜 

分 类 号：R587.1[医药卫生—内分泌]