芪附汤治疗实验性大鼠口腔溃疡作用机理研究  

Anti-inflammatory Effect of Qifu Tang in Rats with Recurrent Oral Ulcertion

作　　者：敬水源 

机构地区：[1]甘孜州人民医院口腔科,四川甘孜626000

出　　处：《中华中医药学刊》2010年第8期1753-1754,共2页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:研究芪附汤对复发性口腔溃疡(ROU)大鼠的抗炎作用。方法:采用免疫方法建立复发性口腔溃疡动物模型,将成模的ROU大鼠随机分为模型对照组、芪附汤治疗组,同时设立假手术组。除芪附汤治疗组大鼠给予10g/(kg·d)芪附汤灌胃以外,其他两组灌胃生理盐水。结果:20天治疗期完成后,与对照组相比,治疗组大鼠溃疡数目减少、直径缩小、持续时间缩短、间歇期明显延长。且治疗组的口腔溃疡炎症细胞因子TNF-α表达水平均明显低,炎性细胞胞核内NF-kBP65低表达。结论:芪附汤对RAU大鼠模型有较好的治疗作用,其机制可能与其抑制炎性细胞的NF-kB的激活,并减少炎症组织TNF-α的表达有关。Recurrent oral ulcertion （ROU） is characterized by recurrent episodes of oral ulcerationin an otherwise healthy individual. Our aim was to evaluate whether or not oral administration of Qifu Tang has an anti-inflammatory effect in ROU rats. Sprague-Dawley rats were randomly assigned to three groups：oral Qifu Tang administered at 10g/kg/d,the vehicle control and sham-operated groups. ROU model was established by injecting the back of rats with galacta of rat＇s oral mucosa. Rats were treated for 20 days with Qifu Tang or 0.9% NaCl. The results showed that rats administered 10 g/kg Qifu Tang had significantly improved the symptom of ROU,compared with rats receiving vehicle. And Qifu Tang inhibit the expression of NF-κB protein and TNF-α. Our findings demonstrated that Qifu Tang exhibited an anti-inflammatory effect through inhibition of the expression of NF-κB protein and serum concentrations of TNF-α. These findings provided new evidence for Qifu Tang in the management of ROU.

关 键 词：芪附汤 口腔溃疡 抗炎 

分 类 号：R285.5[医药卫生—中药学]