复方中药对肝硬化大鼠内毒素血症治疗作用的实验研究  

Experimental Study on Therapeutic Effect of Chinese Traditional Compound Medicine to Endotoxemia in Liver Cirrhotic Rats

作　　者：王宇芳[1] 过建春[1] 施军平[1] 石伟珍[1] 荀运浩[1] 娄国强[1] 

机构地区：[1]杭州市第六人民医院中西医结合肝病科,浙江杭州310014

出　　处：《中华中医药学刊》2010年第8期1760-1761,共2页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:观察复方中药对肝硬化大鼠内毒素血症的治疗作用。方法:采用小剂量内毒素对肝硬化大鼠尾静脉注射制成内毒素血症模型。以复方中药为治疗组,生理盐水为对照组,观察对肝硬化内毒素血症大鼠的肝功能、血氨(BA)、内毒素、肝组织病理炎症活动度等的影响。结果:复方中药组对大鼠的肝功能、血氨、内毒素、肝组织病理炎症活动度等改善优于对照组。结论:由虎杖、生山楂、酸枣仁、蒲公英、石菖蒲、茵陈等组成的复方中药对肝硬化大鼠内毒素血症有显著的治疗作用,可能通过改善肝功能情况、减轻肝脏炎症活动、抑制肠道对氨类物质的吸收,降低血氨水平以及降低机体对内毒素的敏感性等机制发挥作用。Objective：To study the therapeutic effect of Chinese traditional compound medicine to endotoxemia in liver cirrhotic rats. Methods：The endotoxemia model of liver cirrhosis rats w was made by infused with endotoxin into the tail vein. Treatment group was given Chinese traditional compound medicine,Control group was treated with normal saline. The hepatic function,blood ammonium（BA）,endotoxin,liver tissue pathology were observed. Results The hepatic function,BA,endotoxin,liver tissue pathology of treatment group were better than that of control group.Conclusion：The effect of the Chinese traditional compound medicines （compose of Polygonum cuspidatum,raw hawthornfruit,seed of Zizyphus jujuba Mill,Mongolian Dandelion Herb and Rhizoma Acoori Graminei ） in endotoxemia in treatment is significant. Its mechanism might be recovering liver function,decreasing inflammatory changes of liver tissue,preventing the absorption of BA,lowering the content of BA,reducing the sensitivity of the body to endotoxin.

关 键 词：复方中药 肝硬化 大鼠 内毒素血症 治疗 

分 类 号：R285.5[医药卫生—中药学]