二甲苯对大鼠记忆功能和c-fos基因表达的影响  

Effects of xylene on learning memory ability and c fos gene expression in rats

作　　者：王秀玲[1,2,3] 笪翠娣[1,2,3] 王旭平 黄显奋[1,2,3] 金锡鹏[1,2,3] 

机构地区：[1]上海医科大学劳动卫生学教研室 [2]中国预防医学科学院劳动卫生与职业病研究所 [3]神经生物国家重点实验室

出　　处：《中华劳动卫生职业病杂志》1999年第2期88-90,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的探讨二甲苯对大鼠学习记忆功能的影响及其机制。方法采用反映学习记忆功能的水迷宫法和步下法测试大鼠神经行为的改变；免疫组化法研究大鼠脑组织ＦＯＳ免疫反应（ＦＯＳＩＲ）阳性胞核的水平。结果二甲苯使大鼠学习记忆能力下降，大脑皮层及海马区内均有较多的ＦＯＳ蛋白阳性细胞。结论二甲苯可损伤大鼠学习记忆能力。Objective To study the effects of xylene on learning and memory ability in rats and its relation with c fos gene expression. Methods Spatial water maze and step down tests were applied to study the effects of xylene on learning and memory ability in rats.Expression of FOS protein in cortical and hippocampus was observed by immunohistochemical method. Results The learning and memory ability was declined and FOS like immunoreactive(FOS IR) nuclei was induced both in cortical and hippocampus in high dose group(500 mg/kg). Conclusion Xylene may damage the learning memory ability of the rats in high dose and there may be a relationship between the declined ability of learning memory ability and c fos gene expression.

关 键 词：二甲苯 神经行为 学习记忆 C-FOS 基因表达 

分 类 号：R996[医药卫生—毒理学]