局部非冻结性冷暴露对豚鼠坐骨神经形态结构及脂质过氧化的影响  

Effects of local non freezing cold exposure on the structure and lipid peroxidation of sciatic nerve in guinea pigs

作　　者：刘贇[1] 翁恩琪[1] 

机构地区：[1]上海华东师范大学环境科学系

出　　处：《中华劳动卫生职业病杂志》1999年第2期95-97,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的研究局部非冻结性冷暴露对豚鼠坐骨神经形态结构及脂质过氧化的影响。方法观察豚鼠后半身受到（４±２）℃局部冷暴露后，坐骨神经的形态结构及超氧化物歧化酶（ＳＯＤ）活力、丙二醛（ＭＤＡ）含量和血液嗜中性粒细胞（ＮＧ）计数的变化。结果冷暴露后坐骨神经呈现进行性的髓鞘变性，以冷暴露后３天最严重；此时坐骨神经ＳＯＤ活力显著下降（Ｐ＜０．０５），ＭＤＡ含量显著升高（Ｐ＜０．０５）。血液ＮＧ计数也呈现与ＭＤＡ含量变化趋势类似的变化。结论局部冷暴露导致的组织脂质过氧化可能是神经变性的重要原因。Objective To study the effects of local cold exposure(4±2)℃ on the structure and lipid peroxidation of sciatic nerve. Methods Morphological changes,superoxide dismutase(SOD) activity,malonaldehyde(MDA) content in sciatic nerve and amount of neutrophilic granulocyte in blood were studied in guinea pigs exposed to cold. Results Progressive myelin degeneration appeared after cold exposure,and became most serious 3 days after cold exposure,while SOD activity decreased ( P <0.05) and MDA content increased( P <0.05) significantly.The change in neutrophilic granulocyte counts was similar to that in MDA content. Conclusion Local non freezing cold exposure could induce lipoperoxidation in nerve tissue,which may be an important cause of myelin degeneration,and neutrophilic granulocyte counts may be related to lipoperoxidation.

关 键 词：冷暴露 髓鞘 坐骨神经 丙二醛 SOD 冷损伤 

分 类 号：R594.2[医药卫生—内科学] R363.123[医药卫生—临床医学]