蛇胆追风丸对肝气郁结、寒凝型血瘀证大鼠模型血液流变学的影响  

Effect of Shedanzhuifeng Pills on Hemorheology of Rats Model of Liver-qi Stagnation and Cold Coagulation Blood Stasis

作　　者：陈丹曼 梁海清 邓慧敏 杨鹊[2] 

机构地区：[1]广州中一药业有限公司,广东广州510530 [2]广州市医药工业研究所药理研究室,广东广州510240

出　　处：《今日药学》2010年第8期18-20,共3页Pharmacy Today

摘　　要：目的考察蛇胆追风丸对肝气郁结、寒凝型血瘀证模型大鼠血液流变学的影响。方法采用皮下注射0.1%肾上腺素与冰水浴相结合的方法造成肝气郁结、寒凝型血瘀证模型,观察蛇胆追风丸对血瘀病理状态下大鼠血液黏度、红细胞压积、红细胞聚集指数、刚性指数、变形指数、电泳指数等的影响。结果蛇胆追风丸能降低血瘀证模型大鼠的全血黏度、全血还原黏度、红细胞聚集指数、刚性指数。结论蛇胆追风丸对肝气郁结、寒凝型血瘀证模型大鼠血液流变学指标有显著改善作用,主要是通过影响红细胞聚集而起作用。Objective To observe the effect of Shedanzhuifeng pills on the hemorrheology of rats model of liver-qi stagnation and cold coagulation blood stasis.Methods The rats model of liver-qi stagnation and cold coagulation blood stasis was constructed by subcutaneous injection of 0.1% epinephrine with ice water bath method,The influence of Shedanzhuifeng pills on blood viscosity,hematocrit,erythrocyte aggregation index,rigidity index,deformation index,index of electrophoresis were observe.Results Shedanzhuifeng pills can lower the whole blood viscosity,whole blood reduced viscosity,erythrocyte aggregation index,and stiffness index in the blood stasis rats model.Conclusion Shedanzhuifeng pills can significantly improve the blood hemorheology index in rats model of liver-qi stagnation,cold coagulation blood stasis.It mainly works through its influence on erythrocyte aggregation.

关 键 词：蛇胆追风丸 血瘀证 血液流变学 

分 类 号：R285.5[医药卫生—中药学]