采用离体外翻肠囊模型进行穿心莲内酯的肠吸收特性研究  

Rat Intestine Absorption Characteristics Study on Andrographolide with Isolated Everted Intestine Model

作　　者：张英丰[1] 李玉洁[2] 杨庆[2] 翁小刚[2] 董宇[3] 朱晓新[2] 

机构地区：[1]广州中医药大学,广州510006 [2]中国中医科学院中药研究所,北京100700 [3]中国中医科学院广安门医院,北京100053

出　　处：《中国实验方剂学杂志》2010年第9期107-110,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金重点项目(30930114),国家自然科学基金项目(30701097);国家“十一五”科技支撑计划课题(2006BAI08B04-4);中国博士后基金项目(20070420509)

摘　　要：目的:考察穿心莲内酯的肠吸收特性。方法:采用离体外翻肠囊模型研究穿心莲内酯在不同肠段、不同浓度下的肠吸收特性,采用HPLC-UVD测定样品浓度,计算吸收速率常数(Ka)。结果:随着药液中穿心莲内酯质量浓度上升,肠吸收速率常数呈线性增加;各个肠段的吸收速率均无显著性差异。结论:穿心莲内酯在小肠内不存在特殊的"吸收窗",在小肠中均为被动扩散吸收。Objective：To study the intestine absorption of andrographolide.Method：The isolated everted intestine model was used to study the absorption in different regions of rat intestine（duodenum,jejunum,ileum,colon）.The samples were collected at different time and determined with HPLC in combination with ultraviolet detector.Result：The intestine absorption rate constant increased along with andrographolide concentration.The absorption rate had no significant difference between different regions of intestines and different andrographolide concentration.Conclusion：The absorption of andrographolide showed passive diffusion process and didn’t contain a special absorption window.

关 键 词：穿心莲内酯 离体外翻肠囊法 肠吸收 

分 类 号：R285.5[医药卫生—中药学]