醒胰降糖灵对试验性糖尿病大鼠NO与ET-1的影响  

Effects of Xingyi Jiangtangling on Experimental in Diabetic Rats

作　　者：贾育新[1] 杨中高[1] 

机构地区：[1]甘肃中医学院,兰州730000

出　　处：《中国实验方剂学杂志》2010年第9期166-168,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：甘肃省教育厅资金资助项目(0505207)

摘　　要：目的:观察醒胰降糖灵对实验性糖尿病大鼠血清一氧化氮(NO)、血浆血管内皮素(ET-1)的影响。方法:首先用一次性大剂量腹腔注射链脲佐菌素,并连续皮下注射甲状腺素造成实验性糖尿病模型,观察对比各药物治疗组与模型组的NO,ET-1变化。结果:醒胰降糖灵和六味地黄汤治疗组不仅能降低大鼠血糖,而且能明显改善NO,ET-1的变化,其中醒胰降糖灵疗效明显优于六味地黄汤阳性药物对照组,有统计学意义(P<0.05)。结论:醒胰降糖灵在纠正NO与ET-1失衡过程中起重要作用,能改善血管的通利,使血流流畅,减少糖尿病并发症的发生。Objective：To observe the effects of Xingyi Jiangtangling on the of serum nitric oxide（NO）and plasma endothelin vessels（ET） in diabetic rats.Method：The model of diabetic rats was established by one-off high-dose intraperitoneal injection of streptozotocin and then concomitant hypodermic injection with thyroid.Then the changes of theNo1-ET will be obtaind through observation and comparison between drug treatment group and the control model.Xingyi jiangtangling and liuweidihuangwan in the treatment group can not only decline the rat blood sugar but improve the changes of the No,ET-1.Result：that of the effects of the Xingyi Jiangtangling are better than the positive control group of Liuweidihuangwan obviously.It was statistically significant（P 0.05）.Conclusion： Xingyi jianggtangling plays an important role in the process of improving blood flowing and reducing diabetic complications when it corrects the unbalanced NO and ET-1.

关 键 词：醒胰降糖灵 糖尿病 一氧化氮 血管内皮素 

分 类 号：R285.5[医药卫生—中药学]