灯盏花素吸收与促进吸收策略的研究进展  

Progress in Research on Absorption of Breviscapine and Strategies for Absorption-Enhancement

作　　者：吴俊珠[1] 严亚[1] 高鹏飞[1] 

机构地区：[1]大理学院药学院,云南大理671000

出　　处：《中国实验方剂学杂志》2010年第9期219-222,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:介绍灯盏花素吸收动力学与促进其吸收策略的研究进展。方法:分析近年相关文献,对灯盏花素及结构修饰物口服、鼻腔给药、肺部给药、经皮给药的吸收特性,以及如何促进吸收采取的措施进行总结。结果:水溶性和脂溶性差、MRP2的外排作用以及胃肠道的首过效应均是导致灯盏花素口服生物利用度低的重要原因。结论:增加水溶性或脂溶性、抑制外排以及采用微粒给药系统均能改善灯盏花素在小肠的吸收;鼻腔、肺部、经皮肤给药也是其可以选择的非侵入性全身治疗给药途径。Objective：To review advances of absorption pharmacokinetics study of scutellarin and strategies for its absorption enhancement.Method： According to the findings made in the related researches,absorption characteristic of scutellarin by peroral,nasal,pulmonary and transdermal delivery and the strategies for its absorption enhancement are summarized.Result： The low oral bioavailability could be attributed to its poor solubility both in water and in oil,MRP2-efflux function and metabolism in the gastrointestinal tract.Conclusion： The oral absorption of scutellarin could be enhanced by improving its solubility either in water or in oil,inhibiting drug efflux and developing micro and nano drug delivery systems.In addition,nasal,pulmonary and transdermal drug delivery might be considered as non-invasive systemic delivery of scutellarin.

关 键 词：灯盏花素 灯盏花乙素 吸收 生物利用度 

分 类 号：R285.5[医药卫生—中药学]