彩色多普勒评价益肺活血颗粒对家兔肺动脉压力的影响  

Influence of Yifei Huoxue Particles on Pulmonary Artery Pressure in Chronic Pulmonary Heart Disease in Rabbits Evaluated by Color Doppler Flow Imaging

作　　者：翟华强[1] 贺声[2] 袁园[1] 沈燕华[2] 欧敏[2] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]海军总医院,北京100037

出　　处：《中国实验方剂学杂志》2010年第10期113-115,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金："十一五"军队课题(2006083001);教育部"博士点"基金(20070026025)

摘　　要：目的:观察益肺活血颗粒对慢性肺源性心脏病(CPHD)家兔肺动脉压力的影响,探讨其改善肺动脉高压的作用机制。方法:采用0.7%FeCl3溶液耳缘静脉注射造模方法建立CPHD家兔模型,随机设立正常组、模型组、卡托普利组及益肺活血颗粒组。彩色多普勒超声检测各组家兔肺动脉内径、右室流出道宽度、右室前壁厚度、右室内径、肺动脉流速、三尖瓣流速以及观察是否有反流。结果:模型组与正常组比较,42d有显著性差异(P<0.01);62d,益肺活血颗粒组与模型组比较,在右室内径、右室流出道、三尖瓣流速方面比较差异有统计学意义(P<0.05)。结论:益肺活血颗粒能缩小右室内径、降低右室流出道、减慢三尖瓣流速,改善CPHD家兔肺动脉压力。Objective：To study the influence of Yifei Huoxue Particles （YFHX） on pulmonary hypertension pathology in the chronic pulmonary heart disease （CPHD） in rabbits. Method：A total of 12 rabbits were randomly divided into 4 groups （normal group,model group,the captopril group,YFHX group）,each group 3,the rabbits in model group,the captopril group and YFHX group were modeled using 0. 7% FeCl3 by ear vein injection. A total of 42 days,the rabbits in the captopril group and YFHX group were given captopril and YFHX accordingly. Then,a total of 20 days,pulmonary vascular injury was observed and compared. Result：Compared with the normal group,the model group showed structural changes in the heart in pulmonary artery diameter,right ventricular outflow tract,right ventricular front wall thickness and right ventricular track. The modeled rabbits showed significant difference compared with their own situation at 0 d and 42 d （P 〈0. 01）,YPHX treatment group are different with the model group for the indicators：Right ventricular outflow tract and tricuspid velocity （ P〈 0. 05）. Conclusion：YFHX can treat the model of CPHD caused by FeCl3 in rabbits,by reducing the right ventricular diameter and the right ventricular outflow tract and slowing down the tricuspid velocity.

关 键 词：肺心病 彩色多普勒 家兔 

分 类 号：R285.5[医药卫生—中药学]