冠心平对异丙肾上腺素致心肌缺血的试验研究  

An Experimental Study of Guanxinping on Isoprenaline-induced Myocardial Ischemia

作　　者：王道成[1,2] 李七一[3] 朱萱萱[4] 严士海[4] 秦晓康[4] 马俊杰[4] 

机构地区：[1]南京中医药大学,南京210029 [2]江苏省扬州市中医院,江苏扬州225009 [3]江苏省中医院,南京210029 [4]江苏省中医院药理实验室,南京210029

出　　处：《中国实验方剂学杂志》2010年第10期143-146,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：康缘中医药科技创新基金项目(HZ0803KY)

摘　　要：目的:观察冠心平对异丙肾上腺素(ISO)致大鼠心肌缺血的影响。方法:采取大鼠scISO(30mg·kg-1)致急性心肌缺血模型,观察冠心平对大鼠血清乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)、丙二醛(MDA)、超氧化物歧化酶(SOD)活性的影响;观察注射ISO后不同时间J点下降情况,心肌病理损伤程度的影响;结果:冠心平各剂量组均可不同程度降低LDH,CK活力降低血清MDA水平,升高SOD水平(P<0.01,P<0.05);明显抑制ISO引起的大鼠心电图J点下降(P<0.05,P<0.01);心肌病理损伤程度明显减轻。结论:冠心平对ISO致大鼠心肌缺血模型具有明显保护作用。Objective：To observe the effect of Guanxinping on myocardial ischemic injury induced by isoprenaline in rats. Method：Rat myocardial ischemia was induced by subcutaneous injection of isoprenaline（30 mg·kg^ -1 ）. The effect of Guanxinping on the lactate dehydrogenase （ LDH）,serum creatine kinase （ CK）,malondial dehyde （MDA）and superoxide dismutase （SOD）was observed. The descent of J point at different time after injection of isoprenaline was examined,and pathological investigation of myocardial injury in rats was carried out. Result：Guanxinping could obviously inhibit the activities of serum CK,LDH,and MDA ,enhance serum SOD activity（P 〈0. 01,P〈 0. 05）. Guanxinping could inhibit descent of J point in rat myocardial ischemia induced by isoprenaline（ P〈 0. 05,P〈 0. 01 ）,and significantly reduce the extent of myocardial pathological damage. Conclusion：Guanxinping can obviously ameliorate myocardial ischemic injury induced by isoprenaline in rat.

关 键 词：冠心平 异丙肾上腺素 J点 心肌缺血 

分 类 号：R285.5[医药卫生—中药学]