Cu(Ⅰ)催化及相转移条件下末端烯(炔)丙基化偶联反应研究  

STUDY ON ALLYLIC OR PROPARGYLIC COUPLING REACTION OF TERMINAL ALKYNE UNDER COPPER (Ⅰ)CATALYSIS AND PHASE TRANSFER CONDITION

作　　者：龚考才[1] 刘林[1] 杜军[1] 杜曦[1] 贾春水[1] 

机构地区：[1]泸州医学院化学教研室,646000

出　　处：《泸州医学院学报》1999年第1期19-22,共4页Journal of Luzhou Medical College

基　　金：四川省教委重点资助

摘　　要：目的：研究CU（Ⅰ）催化及相转移条件下，末端烯（炔）丙基化偶联反应。方法：通过Cu（Ⅰ）催化及相转移催化反应合成十四个目标化合物，并用XRC－1显微熔点仪，Abbe’折光仪，FI-IR170SX光谱法，Finnigan－MAT4510型CC/MS色谱法，FX-90Q1HNMR光谱法对目标化合物进行检测。结果：本文合成反应条件温和稳定，催化剂用量少，收率高，区域选择性好。结论：1，4-烯炔，1，4-二炔是合成国槐尺蠖昆虫信息素组份的主要砌块，本研究对实现国槐尺蠖昆虫信息素合成有重要意义。Objective : To study the allylic or propargylic coupling reaction of terminal alkyne under copper (Ⅰ)catalysis and Phase transfer condition. Methods: 14 destined compounds were synthesized by copper (Ⅰ) catalysis andPhase transfer catalytic reaction and were surveyed and appraised by meens of XRC -1 microscopic meting point meter ,Abbe refractometer, FI -IR170SX spectroscopy, Finingan - MAT4510 GC/MS chromatography , and FX - 90QHNMR spectroscopy . Results: The condition of synthetic reaction is soft and stable, dose of catalyst is minimal,proportion of reclaim superior, regioselectivity good. Conclusion: 1, 4 - Alkene or Alkyne 1, 4 - Diine are importantbuilding block for synthesizing Macaria Eiongaria Leech insect sex Pheromone. The new synthetic methodology has im-portant significance to achieve the synthesis of Macaria Eiongaria Leech Insect sex pheromone.

关 键 词：末端烯(炔) 丙基化 昆虫信息素 烯炔 二炔 铜 

分 类 号：TQ453.401[化学工程—农药化工] O623.12[理学—有机化学]