钾离子通道开放剂对未成年兔心肌的保护作用  

An Experimental Study on Hemodynamics in Myocardial Protection of Immature Rabbits With a Potassium Channel Opener Nicorandil

作　　者：张宏家[1] 刘迎龙[1] 龙村[1] 朱晓东[1] 温复兴[1] 史世勇[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院心外科

出　　处：《中国循环杂志》1999年第2期118-120,共3页Chinese Circulation Journal

摘　　要：目的：探讨钾离子通道开放剂对未成年兔心肌缺血再灌注损伤的保护作用。方法：在改良Ｌａｎｇｅｎｄｏｒｆ模型上，对Ｓｔ．Ｔｈｏｍａｓ液（Ｓ组）及用１０μｍｏｌ／ＬＮｉｃｏｒａｎｄｉｌ强化的Ｓｔ．Ｔｈｏｍａｓ液（Ｓ＋Ｎ组）两种停跳液进行低温缺血再灌注离体心脏实验。观察缺血前、后心功能变化（左心室变化压、左心室舒张末压、最大压力变化速率、心肌含水量及冠状动脉流量等指标）。结果：离体心脏缺血再灌注后，Ｓ＋Ｎ组左心室变化压、左心室舒张末压、最大压力变化速率及冠状动脉流量等指标方面恢复明显好于Ｓ组。结论：Ｎｉｃｏｒａｎｄｉｌ作为新的有效的停跳液成分，可增强Ｓｔ．Ｔｈｏｍａｓ对未成年兔心肌的保护作用。Objective:The purpose of this study is to investigate the effectiveness of Nicorandil,an opener of potassium channels in protecting myocardium of immature rabbit hearts from ischemic reperfusion injury. Methods:On modified Landgendorff apparatus,16 isolated hearts of 7 14 days immature rabbit were divided in two groups randomly:St.Thomas' solution(group S)and St.Thomas' solution plus nicorandil(group S+N)and subjected to 15°C hypothermia,2 hours of ischemia and 1 hour of reperfusion.The preischemia and postischemia myocardial function were assessed by the percentage recovery of left ventricle developed pressure(LVDP),left ventricle end diastolic pressure,±dp/dt max ,mycardial water content,and coronary blood effluent(CBE). Results:Postischemic recovery of LVDP,left ventricular end diastolic pressure(LVEDP),±dp/dt max ,and CBE were significantly better in group S+N than in groups. Conclusion:As an new and effective composition,nicorandil can improve significantly the myocardial protective effect of the St.Thomas solution for immature rabbit hearts.

关 键 词：PCOS 未成年 心肌保护 心肌缺血 再灌注损伤 

分 类 号：R654.1[医药卫生—外科学]