黄丹胶囊对慢性肾衰大鼠血浆环磷酸鸟苷及心钠素的影响  

Effects of Huangdan Capsule on Plasma cGMP and ANP in Rats with Chronic Renal Failure

作　　者：郑坚峰[1,2,3] 洪淑云 陈思源[1,2,3] 陈敬春[1,2,3] 冯新民[1,2,3] 张长弓[1,2,3] 

机构地区：[1]同济医科大学附属协和医院中医科 [2]同济医科大学附属协和医院儿科 [3]同济医科大学药学院植物化学教研室

出　　处：《同济医科大学学报》1999年第2期147-148,共2页Acta Universitatis Medicinae Tongji

摘　　要：制作５／６肾切除大鼠慢性肾衰模型，用黄丹胶囊治疗，观察血浆环磷酸鸟苷（ｃＧＭＰ）、心钠素（ＡＮＰ）等指标，发现黄丹胶囊可以延缓慢性肾衰大鼠ＢＵＮ、Ｓｃｒ增高，并延缓血浆ｃＧＭＰ、ＡＮＰ水平增高。提示，黄丹胶囊可能通过调节水钠代谢，改善肾小球滤过率，通过机体调节，而对血浆ｃＧＭＰ。The model of chronic renal failure (CRF) was made in 5/6 nephrectomized rats, and Huangdan capsule was used to treat these rats. The levels of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) in plasma were determined. The results showed that Huangdan capsule could postpone the increase of the levels of cGMP and ANP,suggesting that by regulating the water and sodium metabolism, Huangdan capsule could ameliorate the glomerular filtration rate, and that Huangdan capsule could lower the levels of cGMP and ANP in plasma via body regulation.

关 键 词：黄丹胶囊 肾功能衰竭 慢性 心钠素 CGMP 

分 类 号：R285.5[医药卫生—中药学] R277.525[医药卫生—中医学]