重症监护病房导管相关性真菌感染危险因素研究  

Catheter-related fungal infection risk factors in ICU

作　　者：黄磊[1] 赵令玺 蔡文训[1] 朱仲生[1] 张赤[1] 姜春玲[1] 张卫星[1] 

机构地区：[1]北京大学深圳医院ICU,广东深圳518036 [2]江西省南丰县人民医院,江西抚州344500

出　　处：《中国实用内科杂志》2010年第8期715-716,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨重症监护病房(ICU)导管相关性真菌感染的危险因素,为早期经验性抗真菌治疗提供依据。方法将2003年2月至2009年4月北京大学深圳医院ICU收治的56例导管相关性感染患者分为真菌感染组(12例)和非真菌感染组(44例),对两组患者多个危险因素进行统计学分析。结果 Lo-gistic回归分析显示,念珠菌定植和腹部外科手术与导管相关性真菌感染密切相关(P<0.05),其OR值分别是19.783和15.063。结论念珠菌定植和腹部外科手术是导管相关性真菌感染的独立危险因素,可用于指导早期经验性抗真菌治疗。Objective To provide evidence for earlier empirical antifungal therapy of catheter-related fungal infection in ICU. Methods Fifty-six patients treated in Peking University Shenzhen Hospital ICU from Feb 2003 to Apr 2009 with catheter-related infection （CRI） in ICU were retrospectively analyzed and divided into fungal infection group （12 patients） and non-fungal infection group （44 patients）. Multiple risk factors were analyzed in these two groups. Results Binary logistic regression revealed that Candida colonization and abdominal surgery were highly correlated with catheter-related fungal infection （ OR = 19. 783,15. 063, respectively, P 〈 0. 05 ）. Conelusion Candida colonization and abdominal surgery are independent risk factors of catheter-related fungal infection and can be used in earlier empirical antifungal therapy.

关 键 词：导管相关性感染 真菌感染 

分 类 号：R5[医药卫生—内科学]