焦炉作业工人血清脂质过氧化物和抗氧化酶研究  

Study on lipid peroxidation and antioxidases in serum of coke oven workers

作　　者：张晓敏[1,2] 潘海珠[1,2] 卢桥发[1,2] 丁焱焱[1,2] 孙恩林[1,2] 海涛[1,2] 张欲曾 陈胜[1,2] 贺涵贞[1,2] 

机构地区：[1]武钢工业卫生与安全技术研究所 [2]同济医科大学职业医学研究所

出　　处：《中国职业医学》1999年第3期6-8,共3页China Occupational Medicine

摘　　要：目的为了探讨焦炉逸散物对作业工人血清脂质过氧化水平的影响。方法对焦炉作业工人４５９人和对照３５６人血清ＳＯＤ、ＧＳＨＰｘ、ＭＤＡ进行了测定分析。结果焦化作业组血清ＳＯＤ活性与对照相比轻度增高，差异无显著性（Ｐ＞０．０５）；ＧＳＨＰｘ活性较对照组明显增高，有非常显著性差异（Ｐ＜０．０１）；而ＭＤＡ与对照组比较无明显变化。结论提示在一定程度上接触焦炉逸散物，可能诱导了机体的氧化适应反应，使得焦炉作业工人抗氧化功能有所增强。Objective To study the effect of lipid peroxidation on workers exposed to coke oven emissions. MethodsThe level of superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and malonydialdehyde (MDA) in serum in 459 coke oven workers and 356 control cases were measured. Results The SOD activity of coke oven workers was only slightly increased than that of control group without significant difference (P>0.05); GSHPx activity was significantly elevated (P<0.01); and the content of MDA had no obvious change. Conclusion The oxidizing adaptive reaction might be induced after long term and low dose exposure to coke oven emissions, then the antioxidizing capacity of coke oven workers might be enhanced.

关 键 词：焦炉作业 脂质过氧化 SOD CSH-Px 肺癌 

分 类 号：R135.1[医药卫生—劳动卫生] R734.202[医药卫生—公共卫生与预防医学]