由天然左旋多巴合成左旋多巴醇的研究  

Synthesis of L-dopa Alcohol From Natural L-Dopamine

作　　者：冯瑞[1] 崔建国[2] 

机构地区：[1]河南南阳医学高等专科学校,河南南阳473058 [2]广西师范学院化学系,广西南宁530001

出　　处：《化工技术与开发》2010年第8期11-12,22,共3页Technology & Development of Chemical Industry

摘　　要：从广西天然黎豆中提取得到的左旋多巴(Ⅰ)为原料,通过酯化反应得到左旋多巴乙酯(Ⅱ)。采用NaBH4-CeCl3、NaBH4-LiCl、NaBH4-CaCl2作为还原体系,在无水乙醇溶剂中,将左旋多巴乙酯(Ⅱ)还原为左旋多巴醇(Ⅲ)。结果表明,采用NaBH4-CeCl3作为还原体系,有产率高,速度快等优点。该反应中首次采用天然氨基酸合成氨基醇,并采用NaBH4-CeCl3作为还原体系这种新的还原方法。L-Dopamine（Ⅰ）was separated from natural Macuna bean in guangxi.It was turned into L-Dopa ethyl ester by esterification.L-dopa alcohol was prepared by the reduction of L-Dopa ethyl ester（Ⅱ）with NaBH4-CeCl3、NaBH4-LiCl、 NaBH4-CaCl2 as the reducing agent in ethanol.The optimum conditions were as followed： with NaBH4-CeCl3 as the reducing agent had the advantages of higher yield and faster response.For the first time synthesis of amino alcohol from natural amino acids in the reaction,it was a new reaction method with NaBH4-CeCl3 as the reducing agent.

关 键 词：左旋多巴 左旋多巴乙酯 左旋多巴醇 还原 

分 类 号：TQ463.2[化学工程—制药化工]