氯喹加伯氨喹八日疗法对间日疟患者治疗效果的评价研究  

Efficacy evaluation on eight-day regimen of chloroquine and primaquine in patients infected with Plasmodium vivax

作　　者：梁桂亮 张再兴[2] 孙晓东[2] 王剑[2] 

机构地区：[1]昆明市第三人民医院检验科,昆明650041 [2]云南省寄生虫病防治所,云南省疟疾研究中心,普洱665000

出　　处：《国际医学寄生虫病杂志》2010年第4期202-204,共3页International JOurnal of Medical Parasitic Diseases

摘　　要：目的 了解我国氯喹加伯氨喹八日疗法对中缅边境地区间日疟患者的治疗效果.方法 便于追踪、满足纳入条件的单纯间日疟患者且同意参加本次研究者被纳入观察.成人给予氯喹口服总剂量1 200 mg（基质）/3 d,D0给予600 mg,D1、D2分别给予300 mg;联合伯氨喹口服总剂量（基质）180 mg/8 d,D0-D7每次的口服剂量是22.5 mg;患者被纳入观察的第1天作为D0,且在D0、D1、D2、D3、D7、D14、D21和D28检查血涂片.结果 共67人纳入本次观察,其中57人完成D28随访观察.原虫无性体平均转阴时间为41.05±14.01 h、配子体平均转阴时间为20.25±12.86 h、原虫平均退热时间为26.29±10.72 h,至D28仍无原虫再现,57例患者临床及原虫治疗成功.结论 中缅边境地区的间日疟患者对我国的八日疗法敏感.Objective To evaluate the efficacy of 8-day regimen of chloroquine-primaquine for treatment of Plasmodium vivax malaria at China-Myanmar border area. Methods To facilitate tracking, the uncomplicated vivax malaria infected patients who met the inclusion requirements and agreed to participate in the study were enrolled. Adults were given chloroquine orally at a total dose of 1 200 mg divided into 3 d as 600 mg at D0 followed by 300 mg daily at D1 and D2, combined with primaquine orally at a total dose of 180 mg（base）divided into 8 d as 22.5 mg/d from D0 to D7. The first day of patient enrollement was regarded as D0 and blood smear were examined on D0, D1, D2, D3, D7, D14, D21 and D28. Results Total of 67 patientswere enrolled for the study and 57 of them completed the clinical observation of 28 days. The mean asexual parasite clearance time was 41.05 ± 14.01 h, and the mean gametocyte clearance time was 20.25 ± 12.86 h, the mean fever clearance time was 26.29 ± 10.72 h. No recurrence of the parasites occured till D28. All 57 patients were cured clinically and parasitologically. Conclusion The patients infected with Plasmodium vivax malaria at China-Myanmar border areas are sensitive to 8-day regimen of chloroquine-primaquine.

关 键 词：氯喹 伯氨喹 间日疟原虫 八日疗法 中缅边境 

分 类 号：R531.3[医药卫生—内科学]