血清孕酮联合β-人绒毛膜促性腺激素检测在异位妊娠早期诊断及保守治疗中的价值  

Application of the serum Pregestevore and β-HCG in the early diagnosis and conservative therapy of ectopic pregnancy

作　　者：邱振华[1] 曾再祥[1] 舒云华[1] 戚子惠[1] 黄金波[1] 

机构地区：[1]广东省茂名市人民医院检验科,525000

出　　处：《国际检验医学杂志》2010年第7期660-661,664,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨联合检测血清孕酮(P)和β-人绒毛膜促性腺激素(β-HCG)在异位妊娠早期诊断与保守治疗中的临床应用价值。方法运用化学发光免疫分析技术检测62例异位妊娠患者和80例正常宫内早孕孕妇血清β-HCG和P水平,分别作为异位妊娠组和正常妊娠组,对检测数据进行统计分析。结果异位妊娠组各孕周血清β-HCG、P值均显著低于正常妊娠组对应孕周(P<0.01)。接诊48 h后复查血清β-HCG,正常妊娠组β-HCG值上升大于50%者占98.7%(79/80);异位妊娠组β-HCG值上升大于50%者仅占17.7%(11/62),另有6例β-HCG值下降,占9.7%(6/62)。2组比较差异有统计学意义(P<0.001)。以P值12 ng/mL作为是否采用药物保守治疗的临界值,其预测成功的灵敏度和特异度分别为96.88%和100.00%。结论动态监测血清β-HCG和孕酮水平对异位妊娠早期诊断具有重要的临床应用价值。血清孕酮值可作为预测异位妊娠药物保守治疗成败的重要参考指标。Objective To discuss the value of blood serum progesterone and β-HCG examination in eetopie pregnancy early time diagnosis and in treatment way choice. Methods Serum progesterone and β HCG levels with Chemiluminesence lmmunoassay were detected 62 cases of ectopic pregnancy and 80 cases of normal intrauterine pregnancy, respectively, as the experimental group and control group. Results Ectopic pregnancy group of serum β-HCG and progesterone values were significantly lower than the corresponding normal intrauterine age pregnancy group（P〈0.01）. Admissions after 48 hours, serum β-HCGincreased by 50% accounted for 98.7% （79/80） ;ectopic pregnancy group β-HCG values have increased by 50% accounted for 17.7% （11/62）, and another six eases of β-HCG value decreased,accounting for 9.7%0 （6/62）. A very significant difference between the two groups（P〈 0. 001）. 12ng/ml progesterone value is a threshold as whether to adopt the critical value of conservative treatment of drugs and the sensitivity and specificity of predicting the prognosis were 96.88% and 100%. Conclusion Detection of Serums3 HCG and progesterone has important clinical value in the early diagnosis of ectopic pregnancy. Serum progesterone values maybe one of the important reference index to predict whether conservative treatment success or not.

关 键 词：绒毛膜促性腺激素 β亚基 人 孕酮 妊娠 异位 治疗 

分 类 号：R446.61[医药卫生—诊断学] R714.22[医药卫生—临床医学]