VEGF及其受体基因多态性与有氧运动能力表型的关联研究  

Association Study of VEGF and Its Receptors Genes Polymorphisms with Aerobic Performance Phenotypes

作　　者：聂晶[1] 胡扬[2] 席翼[3] 文立[3] 何子红[4] 

机构地区：[1]江西师范大学,江西南昌330022 [2]北京体育大学,北京100084 [3]天津体育学院,天津300381 [4]国家体育总局体育科学研究所,北京100061

出　　处：《体育科学》2010年第8期77-84,96,共9页China Sport Science

基　　金：国家科技部资助课题(2003BA904B04)

摘　　要：目的:探讨血管内皮生长因子(VEGF)及其受体基因多态性与有氧运动能力表型的关联。方法:102名中国北方汉族男子进行18周长跑训练,测试训练前后的V.O2max、12km/h跑速下的RE和心室结构功能指标。用PCR-RFLP分析VEGF基因SNP/C-2578A、VEGFR1基因SNP/A+193019G以及VEGFR2基因SNP/A+18487T。结果:3个多态位点与V.O2max、RE的初始值及训练敏感性均不关联,但与部分心室结构和/或功能指标的初始值及训练敏感性有关联。其中SNP/C-2578A的携A等位基因者、SNP/A+193019G的AA基因型者和SNP/A+18487T的AT、AA基因型者均表现出较好的适应性变化。结论:VEGF基因SNP/C-2578A、VEGFR1基因SNP/A+193019G以及VEGFR2基因SNP/A+18487T可以作为预测18周长跑训练后部分心室结构和/或功能指标敏感性差异的分子遗传学标记。但还需加大样本量进一步验证。Objective：To explore the association between VEGF and its receptors genes polymorphisms and aerobic performance phenotypes. Methods：102 young men of Han nationality in northern China underwent an 18-week long-distance running program. VO2max,RE and left ventricular structure and function were tested before and after training. The genotypes were examined in VEGF and its receptors genes by PCR-RFLP. Results： It was found that no significant differences in baseline levels and the response to training of VO2max and RE between VEGF and its receptors genotypes were observed. However,there was an association between VEGF and its receptors genes polymorphisms and left ventricular structure and function. The carriers of the A allele （CA ＋ AA genotypes） in SNP/C-2578A of VEGF gene,AA genotypes in SNP/A＋193019G of VEGFR1 gene and AT or AA genotypes in SNP/A＋18487T of VEGFR2 gene were better in left ventricular structure and function. Conclusion： The-2578C/A genetic polymorphism of VEGF gene,the ＋193019A/G genetic polymorphism of VEGFR1 gene and the ＋18487A/T genetic polymorphism of VEGFR2 gene may be the genetic markers for the response of left ventricular function to 18-week long-distance running. But the sample size would need to be expanded further.

关 键 词：血管内皮生长因子 受体 基因多态性 最大耗氧量 跑节省化 心功能 有氧运动 

分 类 号：G804.7[文化科学—运动人体科学]