淫羊藿水煎液对去势家兔颌骨缺损愈合的影响  

Impact of Epimedium Decoction on Healing of Mandibular Defect in Ovariectomized Rabbits

作　　者：裴玉岩[1] 李凌志[2] 张海亮[3] 邵伟然[1] 关键[1] 于江[4] 

机构地区：[1]黑龙江省佳木斯大学口腔医学院,佳木斯市154004 [2]上海交通大学附属第九人民医院口腔颌面外科,上海市200025 [3]郑州人民医院口腔科,郑州市450003 [4]大连医科大学美容医学院,大连市116041

出　　处：《医药论坛杂志》2010年第14期1-2,5,共3页Journal of Medical Forum

基　　金：黑龙江省教育厅科学技术研究项目(11531450)

摘　　要：目的观察和分析淫羊藿对去势雌性家兔下颌骨骨缺损愈合的影响,为临床上应用淫羊藿抑制骨质疏松、促进骨缺损愈合提供理论依据。方法雌性哈尔滨大白兔27只建立骨缺损和骨质疏松模型,随机分三组,去势对照组、去势实验组和空白对照组。去势对照组及空白对照组每天给予6g/kg生理盐水喂养,去势实验组给6g/kg淫羊藿煎液喂养,分别于4、12周处死。血清骨钙素、骨密度分析、组织学及扫描电镜观察。结果在4周时,去势实验组、去势对照组与空白对照组无明显差异。12周时骨缺损处,去势实验组、空白对照组与去势对照组有明显差异,并且去势实验组与空白对照组相似。结论淫羊藿能明显增加颌骨骨缺损处骨密度,抑制去势家兔颌骨骨缺损处骨量丢失和骨小梁结构的破坏。Objective To observe and evaluate the healing effects of Epimedium on mandibular bone defect of ovariectomized female rabbits.Methods Female Harbin rabbits （n=27） were randomly divided into 3 groups：ovariectomized group and control group,normal saline （6g/kg） was given;ovariectomized group and therapy group,the decoction of Epimedium （6g/kg） was given;sham group,normal saline （6 g/kg） was given.These rabbits were killed in 4 weeks and 12 weeks,respectively.Evaluated Spongy Bone of restructuring mandibular by bone density,histology,bone histomorphometry and scanned electron microscopy.Results The experimental results in 3 groups are no obvious differences in 4 weeks.In bone defect compared with ovariectomized group,the results in therapy group and control group are significantly different.The result in therapy group is similar with control group in 12 weeks.Conclusion Epimedium could increase bone density of jaw bone,restrain the bone loss of mandibular bone defect of ovariectomized rabbits and structure of trabecular bone wrecking.

关 键 词：淫羊藿 骨质疏松 骨缺损 下颌骨 骨密度 

分 类 号：R332[医药卫生—人体生理学]