废弃药渣中残留泰乐菌素降解菌的筛选  

Screening of Degrading Bacteria for Tylosin Residue in Pharmaceutical Waste

作　　者：马玉龙[1,2] 张作义[1] 刘宁普[1] 谢丽[1,2] 黄越[1] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021 [2]宁夏天然药物工程技术研究中心,宁夏银川750021

出　　处：《环境科学研究》2010年第8期1076-1080,共5页Research of Environmental Sciences

基　　金：教育部新世纪优秀人才支持计划项目(NCET-06-0913);宁夏自然科学基金项目(NZ0819);宁夏环境科学研究项目

摘　　要：发酵法生产抗生素过程中会产生大量废弃药渣.由于残留抗生素的存在,极大地限制了药渣的资源化利用.以泰乐菌素药渣为研究对象,采用微生物法探讨降解药渣中残留泰乐菌素的方法.结果表明:从长期堆放泰乐菌素药渣附近土壤中筛选到可降解药渣残留泰乐菌素的菌株,将该菌株以10%的接种量,在30～35℃,pH为7的条件下,发酵处理泰乐菌素药渣120h后,微生物法未检出残留泰乐菌素的存在.提示利用微生物法可以消除药渣中残留泰乐菌素,从而为泰乐菌素药渣有效处理提供可鉴方法.A mass of pharmaceutical waste is produced during antibiotic production by fermentation. The resource utilization of pharmaceutical waste is restricted greatly because of the existence of antibiotic residue. The aim of this study was to investigate a microbiological method to degrade tylosin residue in pharmaceutical waste. The results showed that tylosin-degrading bacteria were screened from the soil on which the tylosin pharmaceutical waste was long stacked. Tylosin was not detected in the pharmaceutical waste after fermentation with the tylosin-degrading bacteria for 120 h with conditions of initial bacteria concentration 10% ,temperature 30-35 ℃ ,and pH 7. This indicates that tylosin residue in pharmaceutical waste can be eliminated by using the microorganism. The results obtained from the present study provide a reference method for treatment of tylosin pharmaceutical waste.

关 键 词：泰乐菌素 药渣 降解菌 筛选 

分 类 号：X705[环境科学与工程—环境工程]